Australian Water Quality Centre, 250 Victoria Square, GPO Box 1751, Adelaide, SA 5000, Australia.
Water Res. 2012 Apr 1;46(5):1576-83. doi: 10.1016/j.watres.2011.11.019. Epub 2011 Nov 13.
A growing list of freshwater cyanobacteria are known to produce toxic agents, a fact which makes these organisms of concern to water authorities. A cultured strain of Limnothrix (AC0243) was recently shown to have toxic effects in in vitro bioassays. It did not produce any of the known cyanobacterial toxins. The intrapertoneal toxicity of aqueous extracts of the material was therefore tested in mice to determine whether the observed effects might be of public health relevance to drinking water supplies. The results indicate that Limnothrix AC0243 is acutely toxic to mice, causing widespread cellular necrosis in the liver, kidneys and gastrointestinal tract within 24 h of exposure. Sub-lethal effects lasted at least 7 d. These results suggest that Limnothrix AC0243 produces a novel toxin ("Limnothrixin") and that further work is therefore urgently required to quantify the potential public health implications.
越来越多的淡水蓝藻被证实能够产生有毒物质，这一事实引起了水务部门的关注。最近的体外生物检测显示，培养的 Limnothrix（AC0243）菌株具有毒性作用。该菌株并没有产生任何已知的蓝藻毒素。因此，研究人员对该物质的水提物进行了腹腔内毒性测试，以确定观察到的影响是否与饮用水供应有关。结果表明，Limnothrix AC0243 对小鼠具有急性毒性，暴露 24 小时内会导致肝脏、肾脏和胃肠道广泛的细胞坏死。亚致死效应至少持续 7 天。这些结果表明，Limnothrix AC0243 产生了一种新型毒素（“Limnothrixin”），因此需要进一步的工作来量化其对公共健康的潜在影响。
