Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Department of General Surgery, Navy General Hospital, Beijing, China.
Cell Prolif. 2019 Mar;52(2):e12555. doi: 10.1111/cpr.12555. Epub 2018 Dec 4.
The evolution of chronic inflammatory diseases is thought to be due to a combination of host genetic variations and environmental factors that include the alteration of intestinal flora, termed "dysbiosis." The intestinal mucosal barrier includes a chemical barrier and physical barrier that have important roles in protecting the intestine against inflammatory injury. The chemical barrier includes antimicrobial peptides (AMPs), and the physical barrier includes a mucous layer, a monolayer of intestinal epithelial cells and cell junctions. The intestinal mucosal barrier is not a static barrier, but rather, it strongly interacts with the gut microbiome and cells of the immune system. Correct expression of AMPs, together with mucus and balanced epithelial cell proliferation, prevents the occurrence of disease. NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, participates in the progression of intestinal inflammation and enteric pathogen infections. It has become apparent in recent years that NLRP6 is important in disease pathogenesis, as it responds to internal ligands that lead to the release of AMPs and mucus, thus regulating the regeneration of intestinal epithelial cells. This review summarizes the activation of NLRP6 and its protective role in the intestinal epithelial cell.
慢性炎症性疾病的发生被认为是宿主遗传变异和环境因素共同作用的结果，其中包括肠道菌群的改变，即“菌群失调”。肠道黏膜屏障包括化学屏障和物理屏障，它们在保护肠道免受炎症损伤方面发挥着重要作用。化学屏障包括抗菌肽（AMPs），物理屏障包括黏液层、单层肠上皮细胞和细胞连接。肠道黏膜屏障不是一个静态的屏障，而是与肠道微生物群和免疫系统细胞强烈相互作用。AMP 的正确表达、黏液的产生和上皮细胞的平衡增殖可防止疾病的发生。核苷酸结合域富含亮氨酸重复序列（NLR）家族中的核苷酸结合域，富含亮氨酸重复序列（NLR）先天免疫受体家族成员 NLRP6 参与肠道炎症和肠道病原体感染的进展。近年来，NLRP6 在疾病发病机制中的重要性变得明显，因为它对导致 AMP 和黏液释放的内源性配体作出反应，从而调节肠上皮细胞的再生。本综述总结了 NLRP6 的激活及其在肠上皮细胞中的保护作用。
