Division of Neurology, Hospital Universitário Oswaldo Cruz of the Universidade de Pernambuco, Recife, Brazil.
Postgraduate program in Neuropsychiatry and Behavioral Sciences of the Universidade Federal de Pernambuco, Recife, Brazil.
Headache. 2019 Jan;59(1):77-85. doi: 10.1111/head.13460. Epub 2018 Dec 5.
This study evaluated the association between migraine and the markers of carotid artery disease.
Migraine increases the risk of cardiovascular events, but its relationship with vascular dysfunction is unclear.
In this cross-sectional study, middle-aged women with no known cardiovascular diseases underwent clinical, neurological, and laboratory evaluations; pulse wave velocity (PWV) assessment; and carotid artery ultrasonography. We divided the participants based on the presence of migraine and, further, based on the type of migraine. Associations between migraine and carotid thickening (intima-media thickness >0.9 mm), carotid plaques, or arterial stiffening (PWV >10 m/s) were evaluated using a multiple regression analysis.
The study comprised 112/277 (40%) women with migraine, of whom 46/277 (17%) reported having an aura. Compared to the non-migraineurs, the migraine with aura group had an increased risk of diffuse carotid thickening (3/46 [6.8%] vs 2/165 [1.3%], adjusted OR = 7.12, 95% CI 1.05-48.49). Migraine without aura was associated with a low risk of carotid plaques (3/66 [4.7%] vs 26/165 [16.7%], adjusted OR = 0.28, 95% CI 0.08-0.99) and arterial stiffening (21/66 [34.4%] vs 82/165 [51.2%], adjusted OR = 0.39, 95% CI 0.19-0.79). There were no correlations between migraine characteristics and arterial stiffness or carotid thickness measurements.
Migraine with aura is associated with an increased risk of carotid thickening, and migraine without aura is associated with a low risk of carotid plaques and arterial stiffening.
本研究评估了偏头痛与颈动脉疾病标志物之间的关联。
偏头痛增加了心血管事件的风险，但它与血管功能障碍的关系尚不清楚。
在这项横断面研究中，没有已知心血管疾病的中年女性接受了临床、神经和实验室评估；脉搏波速度（PWV）评估；以及颈动脉超声检查。我们根据偏头痛的存在以及偏头痛的类型将参与者进行分组。使用多元回归分析评估偏头痛与颈动脉增厚（内膜中层厚度>0.9 毫米）、颈动脉斑块或动脉僵硬（PWV>10 m/s）之间的关联。
研究共纳入 277 名女性中的 112 名（40%）偏头痛患者，其中 46 名（17%）报告有先兆。与无偏头痛患者相比，有先兆偏头痛患者弥漫性颈动脉增厚的风险增加（3/46 [6.8%] vs 2/165 [1.3%]，调整后的 OR=7.12，95%CI 1.05-48.49）。无先兆偏头痛与颈动脉斑块的低风险相关（3/66 [4.7%] vs 26/165 [16.7%]，调整后的 OR=0.28，95%CI 0.08-0.99）和动脉僵硬（21/66 [34.4%] vs 82/165 [51.2%]，调整后的 OR=0.39，95%CI 0.19-0.79）。偏头痛特征与动脉僵硬或颈动脉厚度测量之间无相关性。
有先兆偏头痛与颈动脉增厚风险增加相关，无先兆偏头痛与颈动脉斑块和动脉僵硬风险降低相关。
