各种肝脏疾病患者的25-羟维生素D血浆水平以及25-羟维生素D对维生素D治疗的反应。

The plasma levels of 25-hydroxyvitamin D in patients with various liver diseases and the response of 25-hydroxyvitamin D to vitamin D treatment.

作者信息

Seino Y, Shimotsuji T, Kai H, Ikehara C, Yabuuchi H

出版信息

Acta Paediatr Scand. 1978 Jan;67(1):39-42. doi: 10.1111/j.1651-2227.1978.tb16274.x.

DOI:10.1111/j.1651-2227.1978.tb16274.x

Abstract

The mean plasma levels of 25-hydroxyvitamin D (25-OH-D) were measured before and after the administration of 2000 units of daily oral vitamin D2 for a period of 2 weeks in 9 normal infants and children, 7 infants with neonatal hepatitis and persistent neonatal hepatitis, and 4 infants with congenital biliary atresia. The mean plasma level of 25-OH-D increased significantly from 19.5 +/- 3.7 (S.E.) ng/ml to 34.0 +/- 6.8 (S.E.) ng/ml after administration of vitamin D2 in controls (p less than 0.05). The mean plasma level of 25-OH-D also increased from 8.0 +/- 2.1 (S.E.) ng/ml to 22.1 +/- 2.6 (S.E.) ng/ml after vitamin D treatment in hepatitis group (p less than 0.05). In patients with congenital biliary atresia, vitamin D treatment did not affect eh plasma levels of 25-OH-D.

摘要

对9名正常婴幼儿、7名患有新生儿肝炎和持续性新生儿肝炎的婴儿以及4名患有先天性胆道闭锁的婴儿，在每日口服2000单位维生素D2、持续2周前后，测量其血浆25-羟维生素D（25-OH-D）的平均水平。对照组在给予维生素D2后，25-OH-D的平均血浆水平从19.5±3.7（标准误）ng/ml显著升高至34.0±6.8（标准误）ng/ml（p<0.05）。肝炎组在维生素D治疗后，25-OH-D的平均血浆水平也从8.0±2.1（标准误）ng/ml升高至22.1±2.6（标准误）ng/ml（p<0.05）。在先天性胆道闭锁患者中，维生素D治疗未影响25-OH-D的血浆水平。