Fröhling P T, Kokot F, Vetter K, Kuska J, Kaschube I, Pietrek J
Nephron. 1980;26(3):116-20. doi: 10.1159/000181965.
The present study was aimed at answering the following two questions: (1) What is the effect of high dose vitamin D treatment on the serum level of 25-hydroxyvitamin D (25-OH-D) in patients with chronic renal failure (CRF)? (2) Is there any effect of urinary protein loss on the serum 25-OH-D levels during treatment with pharmacological doses of vitamin D? 42 patients with CRF were studied. They were treated conservatively by a low protein diet and received 15 mg of vitamin D2 once a week. Long-term administration of vitamin D caused a significant (5- to 7-fold) increase of plasma 25-OH-D level irrespective of the degree of proteinuria. This increase was noted only during the first 5 months of vitamin D2 treatment. Surprisingly only in some patients moderate hypercalcemia (> 2.75 mmol/l) was found. From the results obtained it is concluded that (1) patients with CRF differ from normal subjects in handling of high doses of vitamin D and (2) high dosage treatment with vitamin D may prevent hypocalcemia in patients with CRF in spite of high proteinuria.
（1）高剂量维生素D治疗对慢性肾衰竭（CRF）患者血清25-羟维生素D（25-OH-D）水平有何影响？（2）在使用药理剂量维生素D治疗期间，尿蛋白丢失对血清25-OH-D水平有无影响？对42例CRF患者进行了研究。他们接受低蛋白饮食保守治疗，并每周一次接受15mg维生素D2。长期服用维生素D可使血浆25-OH-D水平显著升高（5至7倍），与蛋白尿程度无关。这种升高仅在维生素D2治疗的前5个月出现。令人惊讶的是，仅在部分患者中发现了中度高钙血症（>2.75mmol/l）。从所得结果得出结论：（1）CRF患者在处理高剂量维生素D方面与正常受试者不同；（2）尽管存在高蛋白尿，高剂量维生素D治疗仍可预防CRF患者的低钙血症。
