Buschard K, Rygaard J
Acta Pathol Microbiol Scand C. 1978 Dec;86C(6):277-82. doi: 10.1111/j.1699-0463.1978.tb02591.x.
Diabetes mellitus induced by low dose treatment with streptozotocin in BALB/c mice was passively transferred to syngeneic recipients with a predominantly T-lymphocyte fraction of spleen cells. This fraction was prepared by density centrifugation and passage through an antimouse immunoglobulin coated column. Variation in numbers of injected cells in the range of 10(3) to 10(7) showed that the smaller cell numbers gave the highest blood sugar values. Athymic nude recipients of BALB/c background also developed diabetes following similar transplants. A preliminary result was that the highest blood sugars were seen after transplantation of T-lymphocytes treated by low dose irradiation (200 R). This may reflect a specific effect on T-suppressor lymphocytes.
用低剂量链脲佐菌素处理BALB/c小鼠诱导的糖尿病，通过脾细胞中主要为T淋巴细胞部分被动转移至同基因受体。该部分通过密度离心和经抗小鼠免疫球蛋白包被柱处理制备。注射细胞数量在10³至10⁷范围内变化，结果显示细胞数量越少，血糖值越高。BALB/c背景的无胸腺裸鼠在进行类似移植后也会发生糖尿病。一个初步结果是，低剂量照射（200伦琴）处理的T淋巴细胞移植后血糖最高。这可能反映了对T抑制淋巴细胞的特异性作用。
