Schmitz Lara, McCotter Sean, Kretschmer Matthias, Kronstad James W, Heimel Kai
Institute for Microbiology and Genetics, Department of Molecular Microbiology and Genetics, Georg-August-University-Göttingen, Göttingen, Lower Saxony, D-37077, Germany.
Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
F1000Res. 2018 Nov 19;7. doi: 10.12688/f1000research.16404.1. eCollection 2018.
Biotrophic fungal pathogens of plants must sense and adapt to the host environment to complete their life cycles. Recent transcriptome studies of the infection of maize by the biotrophic pathogen are providing molecular insights into an ordered program of changes in gene expression and the deployment of effectors as well as key features of nutrient acquisition. In particular, the transcriptome data provide a deeper appreciation of the complexity of the transcription factor network that controls the biotrophic program of invasion, proliferation, and sporulation. Additionally, transcriptome analysis during tumor formation, a key late stage in the life cycle, revealed features of the remodeling of host and pathogen metabolism that may support the formation of tremendous numbers of spores. Transcriptome studies are also appearing for other smut species during interactions with their hosts, thereby providing opportunities for comparative approaches to understand biotrophic adaptation.
植物的活体营养型真菌病原体必须感知并适应宿主环境以完成其生命周期。最近关于活体营养型病原体感染玉米的转录组研究，正在为基因表达变化的有序程序、效应子的部署以及养分获取的关键特征提供分子层面的见解。特别是，转录组数据让我们更深入地认识到控制入侵、增殖和孢子形成的活体营养程序的转录因子网络的复杂性。此外，在生命周期的关键后期肿瘤形成过程中的转录组分析，揭示了宿主和病原体代谢重塑的特征，这些特征可能支持大量孢子的形成。关于其他黑粉菌物种与宿主相互作用的转录组研究也不断出现，从而为通过比较方法理解活体营养型适应提供了机会。
