Surov Alexey, Meyer Hans Jonas, Wienke Andreas
Department of Diagnostic and Interventional Radiology, University of Leipzig, Liebigstr. 20, 04103 Leipzig, Germany.
Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Magdeburger Str., 06097 Halle, Germany.
Transl Oncol. 2019 Feb;12(2):375-380. doi: 10.1016/j.tranon.2018.11.005. Epub 2018 Dec 3.
Numerous studies investigated relationships between positron emission tomography and proliferation index Ki-67 in breast cancer (BC) with inconsistent results. The aim of the present analysis was to provide evident data about associations between standardized uptake value (SUV) and expression of Ki-67 in BC.
MEDLINE library, SCOPUS and EMBASE data bases were screened for relationships between SUV and Ki-67 in BC up to April 2018. Overall, 32 studies with 1802 patients were identified. The following data were extracted from the literature: authors, year of publication, number of patients, and correlation coefficients. Associations between SUV and Ki-67 were analyzed by Spearman's correlation coefficient.
Associations between SUV derived from F-FDG PET and Ki-67 were reported in 25 studies (1624 patients). The pooled correlation coefficient was 0.40, (95% CI = [0.34; 0.46]). Furthermore, 7 studies analyzed associations between SUV derived from F-fluorthymidin (FLT) PET and Ki-67 (178 patients). The pooled correlation coefficient was 0.54, (95% CI = [0.37; 0.70]).
SUV correlated moderately with expression of Ki-67 and, therefore, cannot be used as a surrogate marker for tumor proliferation. Further studies are needed to evaluate associations between PET parameters and histopathological findings like hormone receptor status in breast cancer.
众多研究调查了乳腺癌（BC）中正电子发射断层扫描与增殖指数Ki-67之间的关系，但结果不一致。本分析的目的是提供关于标准化摄取值（SUV）与BC中Ki-67表达之间关联的明确数据。
检索MEDLINE数据库、SCOPUS和EMBASE数据库，以查找截至2018年4月BC中SUV与Ki-67之间的关系。总共确定了32项研究，涉及1802例患者。从文献中提取以下数据：作者、发表年份、患者数量和相关系数。通过Spearman相关系数分析SUV与Ki-67之间的关联。
25项研究（1624例患者）报告了F-FDG PET得出的SUV与Ki-67之间的关联。合并相关系数为0.40，（95%CI = [0.34; 0.46]）。此外，7项研究分析了F-氟胸腺嘧啶核苷（FLT）PET得出的SUV与Ki-67之间的关联（178例患者）。合并相关系数为0.54，（95%CI = [0.37; 0.70]）。
SUV与Ki-67的表达呈中度相关，因此不能用作肿瘤增殖的替代标志物。需要进一步研究来评估PET参数与乳腺癌组织病理学结果（如激素受体状态）之间的关联。
