Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom.
Phys Med Biol. 2018 Dec 19;64(1):01TR01. doi: 10.1088/1361-6560/aaf26a.
The linear-quadratic model is one of the key tools in radiation biology and physics. It provides a simple relationship between cell survival and delivered dose: [Formula: see text], and has been used extensively to analyse and predict responses to ionising radiation both in vitro and in vivo. Despite its ubiquity, there remain questions about its interpretation and wider applicability-Is it a convenient empirical fit or representative of some deeper mechanistic behaviour? Does a model of single-cell survival in vitro really correspond to clinical tissue responses? Is it applicable at very high and very low doses? Here, we review these issues, discussing current usage of the LQ model, its historical context, what we now know about its mechanistic underpinnings, and the potential challenges and confounding factors that arise when trying to apply it across a range of systems.
线性二次模型是放射生物学和物理学的关键工具之一。它提供了细胞存活与所给予剂量之间的简单关系：[公式：见文本]，并已广泛用于分析和预测体外和体内电离辐射的反应。尽管它无处不在，但对于其解释和更广泛的适用性仍存在一些问题——它是一种方便的经验拟合还是代表了一些更深层次的机制行为？体外单细胞存活模型真的与临床组织反应相对应吗？它适用于非常高和非常低的剂量吗？在这里，我们回顾了这些问题，讨论了 LQ 模型的当前使用情况、它的历史背景、我们现在对其机制基础的了解，以及在尝试将其应用于一系列系统时出现的潜在挑战和混杂因素。
