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迈向基于氧化石墨烯共价接枝的多参数多孔硅传感器用于生物传感应用

Toward Multi-Parametric Porous Silicon Transducers Based on Covalent Grafting of Graphene Oxide for Biosensing Applications.

作者信息

Moretta Rosalba, Terracciano Monica, Dardano Principia, Casalino Maurizio, De Stefano Luca, Schiattarella Chiara, Rea Ilaria

机构信息

Institute for Microelectronics and Microsystems, Unit of Naples, Naples, Italy.

Department of Chemical Sciences, "Federico II" University of Naples, Naples, Italy.

出版信息

Front Chem. 2018 Nov 22;6:583. doi: 10.3389/fchem.2018.00583. eCollection 2018.

DOI:10.3389/fchem.2018.00583
PMID:30525029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6261979/
Abstract

Graphene oxide (GO) is a two-dimensional material with peculiar photoluminescence emission and good dispersion in water, that make it an useful platform for the development of label-free optical biosensors. In this study, a GO-porous silicon (PSi) hybrid device is realized using a covalent chemical approach in order to obtain a stable support for biosensing applications. Protein A, used as bioprobe for biosensing purposes, is covalently linked to the GO, using the functional groups on its surface, by carbodiimide chemistry. Protein A bioconjugation to GO-PSi hybrid device is investigated by atomic force microscopy (AFM), scanning electron microscopy (SEM), water contact angle (WCA) measurements, Fourier transform infrared (FTIR) spectroscopy, steady-state photoluminescence (PL), and fluorescence confocal microscopy. PSi reflectance and GO photoluminescence changes can thus be simultaneously exploited for monitoring biomolecule interactions as in a multi-parametric hybrid biosensing device.

摘要

氧化石墨烯（GO）是一种二维材料，具有独特的光致发光发射特性且在水中具有良好的分散性，这使其成为开发无标记光学生物传感器的有用平台。在本研究中，采用共价化学方法实现了一种氧化石墨烯 - 多孔硅（PSi）混合器件，以便获得用于生物传感应用的稳定支撑体。用作生物传感生物探针的蛋白A通过碳二亚胺化学方法利用其表面的官能团与氧化石墨烯共价连接。通过原子力显微镜（AFM）、扫描电子显微镜（SEM）、水接触角（WCA）测量、傅里叶变换红外（FTIR）光谱、稳态光致发光（PL）和荧光共聚焦显微镜研究蛋白A与氧化石墨烯 - 多孔硅混合器件的生物共轭。因此，如在多参数混合生物传感器件中一样，PSi反射率和GO光致发光变化可同时用于监测生物分子相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/687cba3fc701/fchem-06-00583-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/9bdcf23bc288/fchem-06-00583-g0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/907fb8493d9c/fchem-06-00583-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/7fc686d67904/fchem-06-00583-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/10d4b2f03813/fchem-06-00583-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/2bf3a327dab0/fchem-06-00583-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/687cba3fc701/fchem-06-00583-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/9bdcf23bc288/fchem-06-00583-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/d96b1f91073a/fchem-06-00583-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/fc33aef39430/fchem-06-00583-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/907fb8493d9c/fchem-06-00583-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/7fc686d67904/fchem-06-00583-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/10d4b2f03813/fchem-06-00583-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/2bf3a327dab0/fchem-06-00583-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/6261979/687cba3fc701/fchem-06-00583-g0008.jpg

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2
Graphene oxide as an optical biosensing platform.氧化石墨烯作为一种光学生物传感平台。
Adv Mater. 2012 Jul 3;24(25):3298-308. doi: 10.1002/adma.201200373. Epub 2012 May 25.
3
Tunable photoluminescence from graphene oxide.氧化石墨烯的可调谐光致发光
多孔硅光学器件：生物传感应用的最新进展。
Sensors (Basel). 2021 Feb 13;21(4):1336. doi: 10.3390/s21041336.
4
PNA-Based Graphene Oxide/Porous Silicon Hybrid Biosensor: Towards a Label-Free Optical Assay for Brugada Syndrome.基于肽核酸的氧化石墨烯/多孔硅混合生物传感器：迈向无标记光学检测的布加综合征检测方法
Nanomaterials (Basel). 2020 Nov 10;10(11):2233. doi: 10.3390/nano10112233.
5
Maltodextrin-modified graphene oxide for improved enantiomeric separation of six basic chiral drugs by open-tubular capillary electrochromatography.麦芽糊精修饰的氧化石墨烯用于开管毛细管电色谱对手性药物对映体的拆分。
Mikrochim Acta. 2019 Dec 17;187(1):55. doi: 10.1007/s00604-019-4037-x.
6
Nanosilicon-Based Composites for (Bio)sensing Applications: Current Status, Advantages, and Perspectives.用于（生物）传感应用的纳米硅基复合材料：现状、优势与展望
Materials (Basel). 2019 Sep 6;12(18):2880. doi: 10.3390/ma12182880.
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Porous Silicon-Based Aptasensors: The Next Generation of Label-Free Devices for Health Monitoring.基于多孔硅的适体传感器：用于健康监测的下一代无标记设备。
Molecules. 2019 Jun 13;24(12):2216. doi: 10.3390/molecules24122216.
Angew Chem Int Ed Engl. 2012 Jul 2;51(27):6662-6. doi: 10.1002/anie.201200474. Epub 2012 May 23.
4
Biological and chemical sensors based on graphene materials.基于石墨烯材料的生物和化学传感器。
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5
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