微小RNA：胰腺导管腺癌中转化生长因子-β信号通路的新型调节因子
microRNAs: Novel regulators of the TGF-β pathway in pancreatic ductal adenocarcinoma.
作者信息
Ottaviani Silvia, Castellano Leandro
机构信息
Department of Surgery and Cancer, Division of Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM), London, UK.
School of life Sciences, University of Sussex, Brighton, UK.
出版信息
Mol Cell Oncol. 2018 Aug 13;5(6):e1499066. doi: 10.1080/23723556.2018.1499066. eCollection 2018.
Abstract
We identified that transforming growth factor-β (TGF-β) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC). Importantly let-7a, despite originating from MIR100HG, remains unchanged because post-transcriptionally repressed by lin-28 homolog B (LIN28B). A novel method for global miRNA-target discovery identified that miR-100/125b regulates crucial PDAC pathways.
摘要
我们发现，转化生长因子-β（TGF-β）可诱导长链非编码RNA（lncRNA）MIR100HG及其宿主微小RNA（miRNA）miR-100和miR-125b，以调节其在胰腺导管腺癌（PDAC）中的反应。重要的是，尽管let-7a源自MIR100HG，但由于其在转录后被lin-28同源物B（LIN28B）抑制，所以其表达保持不变。一种用于全局miRNA靶点发现的新方法确定，miR-100/125b可调节关键的PDAC通路。
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1
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2
Contextual determinants of TGFβ action in development, immunity and cancer.转化生长因子β（TGFβ）在发育、免疫和癌症中作用的情境决定因素。
Nat Rev Mol Cell Biol. 2018 Jul;19(7):419-435. doi: 10.1038/s41580-018-0007-0.
3
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Cell. 2016 Jun 2;165(6):1401-1415. doi: 10.1016/j.cell.2016.04.033. Epub 2016 May 12.
4
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Genes Dev. 2016 Feb 15;30(4):355-85. doi: 10.1101/gad.275776.115.
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