1 University of Western Ontario, 339 Windermere Rd, London, ON N6A 5A5, Canada.
Benef Microbes. 2019 Feb 8;10(1):27-32. doi: 10.3920/BM2018.0029. Epub 2018 Dec 10.
Gut microbiome interaction goes beyond commensal function as vitamin production or support nutrients digestion. It also interplays with the host immune system and may be related to the development of immune-mediated diseases. Multiple sclerosis patients have dysbiosis compared to healthy individuals. But how this relates to disease development and severity is still uncertain. Dietary change including probiotic mixtures or ketogenic regimen has proven to change microbiome in multiple sclerosis (MS) subjects to one similar to healthy controls. However, proof of clinical benefits is lacking. We dissert on current knowledge about immune system and gut bacteria interactions. We discuss faecal microbial transplantation as a potential intervention to ameliorate gut dysbiosis in MS as well as the caveats of a clinical trial design.
肠道微生物组的相互作用不仅限于产生维生素或支持营养物质消化的共生功能。它还与宿主免疫系统相互作用，可能与免疫介导性疾病的发展有关。与健康个体相比，多发性硬化症患者存在肠道菌群失调。但是，这种情况与疾病的发展和严重程度有何关系仍不确定。饮食改变，包括益生菌混合物或生酮饮食，已被证明可使多发性硬化症（MS）患者的微生物组发生变化，使其类似于健康对照组。然而，缺乏临床获益的证据。我们论述了免疫系统和肠道细菌相互作用的现有知识。我们讨论了粪便微生物移植作为改善多发性硬化症肠道菌群失调的一种潜在干预措施，以及临床试验设计的注意事项。
