Yan Fen, Huang Lei, Jiang Yuanxiao, Jiang Canyu, Huang Ya, He Jie, Wang Jie, Hu Gonghua, Zou Lijun, Xu Qi, Zhang Xiaokang, Gao Yanfang
School of Public Health and Health Management, Gannan Medical University, Ganzhou, China.
Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou City, China.
BMC Public Health. 2025 May 30;25(1):2004. doi: 10.1186/s12889-025-23078-4.
Hypertension is a prevalent condition that contributes significantly to the global disease burden. Recent research endeavors have been investigating the potential causal link between metal exposure and the development of hypertension, yet consensus remains elusive. Nevertheless, studies examining the interplay among metal exposure, hypertension, and oxidative stress are relatively limited. This study utilized data from a cross-sectional survey conducted in southern Jiangxi Province, China. We evaluated urinary concentrations of 19 metals, including aluminum and manganese, in conjunction with measurements of systolic and diastolic blood pressures, as well as three oxidative stress biomarkers: glutathione peroxidase (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA). In the monometallic model, chromium, iron, manganese, and molybdenum exhibited positive correlations with blood pressure. These findings were consistent in the mixed exposure model. Conversely, all the aforementioned metals exhibited a negative correlation with GSH and SOD, while demonstrating a positive correlation with MDA. Mediation effect analysis revealed that GSH and SOD mediated the relationships between urinary concentrations of aluminum, iron, manganese, and antimony and blood pressure. In contrast, MDA mediated the associations between urinary silver and antimony and blood pressure. Furthermore, GSH and SOD were identified as mediators in part of the relationship between mixed metal exposure and blood pressure, with mediation rates of 19.09% for GSH and 27.36% for SOD. The results of this study suggest that exposure to both individual and combined metals effects blood pressure levels, which are further associated with changes in oxidative stress levels. Moreover, oxidative stress levels may modulate the changes in blood pressure related to metal exposure, providing a basis for further investigation into the health risks associated with these metal exposures.
高血压是一种普遍存在的疾病，对全球疾病负担有重大影响。最近的研究一直在调查金属暴露与高血压发展之间的潜在因果关系，但尚未达成共识。然而，研究金属暴露、高血压和氧化应激之间相互作用的研究相对有限。本研究利用了在中国江西省南部进行的一项横断面调查的数据。我们评估了19种金属的尿浓度，包括铝和锰，同时测量了收缩压和舒张压，以及三种氧化应激生物标志物：谷胱甘肽过氧化物酶（GSH）、超氧化物歧化酶（SOD）和丙二醛（MDA）。在单金属模型中，铬、铁、锰和钼与血压呈正相关。这些发现在混合暴露模型中是一致的。相反，上述所有金属与GSH和SOD呈负相关，而与MDA呈正相关。中介效应分析表明，GSH和SOD介导了铝、铁、锰和锑的尿浓度与血压之间的关系。相比之下，MDA介导了尿银和锑与血压之间的关联。此外，GSH和SOD被确定为混合金属暴露与血压之间部分关系的中介，GSH的中介率为19.09%，SOD的中介率为27.36%。本研究结果表明，个体和混合金属暴露都会影响血压水平，这进一步与氧化应激水平的变化相关。此外，氧化应激水平可能调节与金属暴露相关的血压变化，为进一步研究这些金属暴露相关的健康风险提供了依据。
