Laboratory of Molecular Virology and Antiviral Research, Department of Clinical and Biological Sciences, University of Torino, Orbassano, Torino, Italy.
Department of Molecular Microbiology, University of Geneva, Geneva, Switzerland.
PLoS One. 2018 Dec 7;13(12):e0208333. doi: 10.1371/journal.pone.0208333. eCollection 2018.
Viral infections are an important cause of death worldwide. Unfortunately, there is still a lack of antiviral drugs or vaccines for a large number of viruses, and this represents a remarkable challenge particularly for emerging and re-emerging viruses. For this reason, the identification of broad spectrum antiviral compounds provides a valuable opportunity for developing efficient antiviral therapies. Here we report on a class of rhodanine and thiobarbituric derivatives displaying a broad spectrum antiviral activity against seven different enveloped viruses including an HSV-2 acyclovir resistant strain with favorable selectivity indexes. Due to their selective action on enveloped viruses and to their lipid oxidation ability, we hypothesize a mechanism on the viral envelope that affects the fluidity of the lipid bilayer, thus compromising the efficiency of virus-cell fusion and preventing viral entry.
病毒感染是全球范围内导致死亡的一个重要原因。不幸的是，目前仍缺乏针对大量病毒的抗病毒药物或疫苗，这对于新兴和重现的病毒来说是一个巨大的挑战。出于这个原因，广谱抗病毒化合物的鉴定为开发有效的抗病毒疗法提供了宝贵的机会。在这里，我们报告了一类罗丹宁和硫代巴比妥酸衍生物，它们对七种不同的包膜病毒具有广谱抗病毒活性，包括对阿昔洛韦耐药的 HSV-2 株，具有良好的选择性指数。由于它们对包膜病毒的选择性作用及其脂质氧化能力，我们推测它们在病毒包膜上的作用机制会影响脂质双层的流动性，从而降低病毒-细胞融合的效率，并阻止病毒进入。
