Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Expert Rev Anti Infect Ther. 2010 Jun;8(6):635-8. doi: 10.1586/eri.10.51.
Evaluation of: Wolf MC, Freiberg AN, Zhang T et al. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc. Natl Acad. Sci. USA 107, 3157-3162 (2010). The emergence and re-emergence of viruses and the widespread antiviral resistance calls for the development of a broad-spectrum strategy for viral infection. The article under review describes an approach to achieve this goal by developing an antiviral rhodanine derivative effective against enveloped viruses targeting the viral lipid membrane. By intercalating into the viral membrane, the compound irreversibly inactivates the virions with virucidal effects. Potential toxic effects on hosts could be minimized by continuous regeneration of cellular membranes. The present strategy exploits the therapeutic window that exists between static viral membranes and biogenic cellular membranes and provides a useful guideline for future research endeavors towards broad-spectrum antiviral approaches for enveloped viruses. Developing a formulation that ensures efficient delivery and pharmacokinetic properties while minimizing systemic toxicity on cell membranes remains a challenge. The advantages and disadvantages of a viral membrane-targeting approach for the control of emerging and re-emerging viruses will be discussed.
Wolf MC、 Freiberg AN、Zhang T 等人。一种针对包膜病毒进入的广谱抗病毒药物。Proc. Natl Acad. Sci. USA 107, 3157-3162 (2010)。病毒的出现和再现以及广泛存在的抗病毒耐药性要求开发一种针对病毒感染的广谱策略。这篇综述文章描述了一种通过开发针对靶向病毒脂质膜的包膜病毒的抗病毒类黄酮衍生物来实现这一目标的方法。该化合物通过插入病毒膜，以具有病毒杀伤作用的方式不可逆地使病毒失活。通过不断再生细胞膜，可以将对宿主的潜在毒性作用降到最低。目前的策略利用了静态病毒膜和生物起源的细胞膜之间存在的治疗窗，并为针对包膜病毒的广谱抗病毒方法的未来研究工作提供了有用的指导。开发一种既能确保有效传递和药代动力学特性，又能最大限度地减少细胞膜全身毒性的制剂仍然是一个挑战。将靶向病毒膜的方法用于控制新发和再现病毒的优缺点将进行讨论。
