Negro Aurelio, De Berti Gianni, Maggi Massimo, Santi Rosaria, Grasselli Chiara, Rossi Ermanno
Second Division of Internal Medicine and Hypertension Unit, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
Neuroradiology Unit, Radiology Department, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
J Cardiol Cases. 2011 Oct 4;4(3):e168-e171. doi: 10.1016/j.jccase.2011.08.008. eCollection 2011 Dec.
Posterior reversible encephalopathy syndrome (PRES) is characterized clinically by headache, altered mental status, visual loss, and seizures. PRES is associated with neuroradiological findings characterized by white matter abnormalities, predominantly in the parieto-occipital regions of the brain. PRES is most often described in cases of hypertensive encephalopathy, eclampsia, renal failure, and immunosuppressive or anticancer therapy. We report a case of PRES associated with severe hypertension in the setting of a progressive renovascular hypertension from bilateral atherosclerotic renal artery stenosis. The pathogenesis of PRES is discussed and the importance of a prompt diagnosis and treatment is emphasized.
后部可逆性脑病综合征(PRES)的临床特征为头痛、精神状态改变、视力丧失和癫痫发作。PRES与神经影像学表现相关,其特征为白质异常,主要位于大脑的顶枕区。PRES最常出现在高血压脑病、子痫、肾衰竭以及免疫抑制或抗癌治疗的病例中。我们报告了一例在双侧动脉粥样硬化性肾动脉狭窄导致的进行性肾血管性高血压背景下与严重高血压相关的PRES病例。本文讨论了PRES的发病机制,并强调了及时诊断和治疗的重要性。