Department of Physiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
Oxid Med Cell Longev. 2018 Nov 11;2018:7342451. doi: 10.1155/2018/7342451. eCollection 2018.
The main factor characteristic for low-grade systemic inflammation typical for obesity is oxidative stress (OS). Reactive oxygen species (ROS) production is higher and more increased in time in the obese patients than in lean subjects.
To assess the effect of ileal transposition (IT) and sham types of bariatric procedures on the antioxidative systems in the liver tissue of Zucker rats (Crl:ZUC Lepr).
21 animals were divided into the experimental groups: control group ( = 7), sham group ( = 7), and IT group ( = 7). Sham and IT animals underwent selected surgery. The concentration of total antioxidant capacity (TAC), total antioxidant status (TOS), and activity of glutathione reductase (glutathione-disulfide reductase, GR, GSR), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), and total superoxide dismutase activity (SOD) were assessed in liver tissue 3 months after surgery.
IT procedure significantly increased TAC when compared to sham and the control group. Animals after IT showed higher levels of TOS when compared to sham procedure. The total amount of TOS was similar in IT and control groups. GPx activity was increased in the groups submitted to the sham and IT surgery in relation to control. GR and CAT activities were significantly higher after IT in comparison to control and sham procedures. Total SOD and MnSOD were significantly higher in sham-operated animals in comparison to IT intervention and control groups.
IT procedure had a positive impact on the diminishing of oxidative stress measured by TAC and TOS markers. The dynamic, adaptive, and protective mechanisms of enzymatic antioxidant systems were observed after the IT but not sham procedure. Nevertheless, 3 months after surgery, the midterm effect of bariatric surgery was observed, which might not fully balance the antioxidative response.
肥胖症典型的低度全身炎症的主要特征因素是氧化应激（OS）。肥胖患者的活性氧（ROS）产生量高于瘦受试者，且随时间的推移增加更多。
评估回肠转位（IT）和假型减重手术对 Zucker 大鼠（Crl：ZUC Lepr）肝组织抗氧化系统的影响。
将 21 只动物分为实验组：对照组（n = 7）、假手术组（n = 7）和 IT 组（n = 7）。假手术和 IT 动物接受了选择性手术。术后 3 个月评估肝组织中总抗氧化能力（TAC）、总抗氧化状态（TOS）、谷胱甘肽还原酶（谷胱甘肽-二硫化物还原酶，GR，GSR）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽 S-转移酶（GST）和总超氧化物歧化酶活性（SOD）的浓度。
与假手术和对照组相比，IT 手术显著增加了 TAC。与 sham 手术相比，IT 术后动物的 TOS 水平更高。IT 和对照组的 TOS 总量相似。与对照组相比， sham 和 IT 手术后的 GPx 活性均增加。与 sham 和 IT 手术相比，GR 和 CAT 活性在 IT 手术后显著升高。与 IT 干预和对照组相比， sham 手术的动物总 SOD 和 MnSOD 明显更高。
IT 手术对 TAC 和 TOS 标志物测量的氧化应激有积极影响。观察到 IT 而不是 sham 手术后酶抗氧化系统的动态、适应性和保护机制。然而，手术后 3 个月观察到了减重手术的中期效果，这可能不能完全平衡抗氧化反应。
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