Rock E P, Saul A J, Taylor D W, Leech J H, Sherwood J A, Howard R J
Howard Hughes Medical Institute, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Infect Immun. 1988 Dec;56(12):3301-4. doi: 10.1128/iai.56.12.3301-3304.1988.
Six culture-adapted knob-positive Plasmodium falciparum parasites, four of which were nonbinding in an in vitro cytoadherence assay, were tested for the presence of the knob-associated histidine-rich protein PfHRP1. Two knob-positive, strongly cytoadherence-positive P. falciparum strains from Aotus monkeys were also examined. All parasites expressed PfHRP1, suggesting that it plays a structural or functional role related to knobs but is not by itself sufficient for cytoadherence of P. falciparum-infected erythrocytes.
对6株适应培养的、有凸起的恶性疟原虫寄生虫进行了检测，以确定是否存在与凸起相关的富含组氨酸蛋白PfHRP1，其中4株在体外细胞黏附试验中无黏附性。还检测了来自夜猴的2株有凸起、细胞黏附性强阳性的恶性疟原虫菌株。所有寄生虫均表达PfHRP1，这表明它在与凸起相关的结构或功能中发挥作用，但自身并不足以使恶性疟原虫感染的红细胞发生细胞黏附。
