European Molecular Biology Laboratory- European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Nucleic Acids Res. 2019 Jan 8;47(D1):D1073-D1079. doi: 10.1093/nar/gky984.
Patient-derived tumor xenograft (PDX) mouse models are a versatile oncology research platform for studying tumor biology and for testing chemotherapeutic approaches tailored to genomic characteristics of individual patients' tumors. PDX models are generated and distributed by a diverse group of academic labs, multi-institution consortia and contract research organizations. The distributed nature of PDX repositories and the use of different metadata standards for describing model characteristics presents a significant challenge to identifying PDX models relevant to specific cancer research questions. The Jackson Laboratory and EMBL-EBI are addressing these challenges by co-developing PDX Finder, a comprehensive open global catalog of PDX models and their associated datasets. Within PDX Finder, model attributes are harmonized and integrated using a previously developed community minimal information standard to support consistent searching across the originating resources. Links to repositories are provided from the PDX Finder search results to facilitate model acquisition and/or collaboration. The PDX Finder resource currently contains information for 1985 PDX models of diverse cancers including those from large resources such as the Patient-Derived Models Repository, PDXNet and EurOPDX. Individuals or organizations that generate and distribute PDXs are invited to increase the 'findability' of their models by participating in the PDX Finder initiative at www.pdxfinder.org.
患者来源肿瘤异种移植（PDX）小鼠模型是一个用于研究肿瘤生物学和测试针对个体患者肿瘤基因组特征定制的化疗方法的多功能肿瘤学研究平台。PDX 模型由各种学术实验室、多机构联盟和合同研究组织生成和分发。PDX 存储库的分布式特性以及用于描述模型特征的不同元数据标准，给确定与特定癌症研究问题相关的 PDX 模型带来了重大挑战。杰克逊实验室和 EMBL-EBI 通过共同开发 PDX Finder 来应对这些挑战，PDX Finder 是一个全面的开放全球 PDX 模型及其相关数据集目录。在 PDX Finder 中，使用之前开发的社区最小信息标准对模型属性进行协调和整合，以支持在原始资源之间进行一致搜索。从 PDX Finder 搜索结果提供了到存储库的链接，以方便模型获取和/或合作。PDX Finder 资源目前包含了来自各种癌症的 1985 个 PDX 模型的信息，包括来自大型资源的信息，如患者来源模型存储库、PDXNet 和 EurOPDX。生成和分发 PDX 的个人或组织被邀请通过参与 www.pdxfinder.org 上的 PDX Finder 计划来提高其模型的“可发现性”。
