Division of Oncology, School of Medicine, St. Louis, MO, USA.
McDonnell Genome Institute, School of Medicine, St. Louis, MO, USA.
Bioinformatics. 2018 Dec 15;34(24):4315-4317. doi: 10.1093/bioinformatics/bty531.
A database of curated genomic variants with clinically supported drug therapies and other oncological annotations is described. The accompanying web portal provides a search engine with two modes: one that allows users to query gene, cancer type, variant type or position for druggable mutations, and another to search for and to visualize, on three-dimensional protein structures, putative druggable sites that cluster with known druggable mutations.
本文描述了一个经过精心整理的基因组变异数据库，其中包含了临床支持的药物治疗方法和其他肿瘤学注释。随附的网络门户提供了一个搜索引擎，具有两种模式：一种允许用户查询基因、癌症类型、变异类型或位置，以查找可用药的突变；另一种则用于搜索和可视化三维蛋白质结构上与已知可用药突变聚集的潜在可用药位点。
