Okura K, Haruta T, Kobayashi Y
Department of Pediatrics, Kobe Central Municipal Hospital, Japan.
J Antimicrob Chemother. 1988 Aug;22(2):207-11. doi: 10.1093/jac/22.2.207.
Meningitis was induced in white rabbits with a non beta-lactamase producing strain of Staphylococcus aureus. There was no significant difference in the CSF level of ceftazidime after simultaneous administration of ceftazidime with ampicillin or after ceftazidime alone. In contrast the percentage CSF penetration of ampicillin decreased from 8.81% after administration of ampicillin alone to 2.77% after the simultaneous administration of ampicillin with ceftazidime. The ratio of AUC in CSF and serum was 19.4% after ampicillin alone and 7.71% after simultaneous administration with ceftazidime. When ceftriaxone was combined with ampicillin there was no effect on the CSF penetration of either drug. Cephalosporins have unpredictable effects on the CSF concentration of ampicillin, probably due to variable effects on the penetration of ampicillin from blood to CSF.
用一株不产β-内酰胺酶的金黄色葡萄球菌诱导白兔患脑膜炎。同时给予头孢他啶和氨苄西林后，脑脊液中头孢他啶的水平与单独给予头孢他啶后相比无显著差异。相比之下，氨苄西林的脑脊液穿透率从单独给予氨苄西林后的8.81%降至与头孢他啶同时给予后的2.77%。单独给予氨苄西林后脑脊液与血清的AUC比值为19.4%，与头孢他啶同时给予后为7.71%。当头孢曲松与氨苄西林联合使用时，对两种药物的脑脊液穿透率均无影响。头孢菌素对氨苄西林在脑脊液中的浓度有不可预测的影响，这可能是由于对氨苄西林从血液到脑脊液的穿透有不同的影响。
