School of Materials Science and Engineering, College of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin, 150040, China.
College of Materials Science and Engineering, Heilongjiang Provincial Key Laboratory of Polymeric Composite Materials, Qiqihar University, Qiqihar, 161006, China.
Mikrochim Acta. 2018 Dec 10;186(1):9. doi: 10.1007/s00604-018-3128-4.
A Cr-based metal-organic framework MIL-101(Cr) was used to load platinum nanoparticles (PtNPs) that were placed on a glassy carbon electrode (GCE). The modified GCE was used as a non-enzymatic xanthine sensor. Compared to bare GCE, it requires a strongly decreased working potential and an increased signal current for xanthine oxidation. This is due to the crystalline ordered structure and large specific surface of the MIL-101(Cr), and to the high conductivity of the Pt NPs. Differential pulse voltammetry (DPV) shows the sensor to have a wide linear range (0.5 - 162 μM), a low detection limit (0.42 μM), and high selectivity. It was applied to the simultaneous determination of dopamine, uric acid, xanthine and hypoxanthine at working potentials of 0.13, 0.28, 0.68 and 1.05 V, respectively (vs. Ag/AgCl) and to quantify xanthine in spiked serum samples. Graphical abstract This is the first report of non-enzymatic xanthine electrochemical sensor based on metal-organic framework loaded with nanoparticles.
采用基于 Cr 的金属有机骨架 MIL-101(Cr) 负载铂纳米粒子 (PtNPs)，将其置于玻碳电极 (GCE) 上。修饰后的 GCE 可用作非酶黄嘌呤传感器。与裸 GCE 相比，它需要更低的工作电位和更高的黄嘌呤氧化信号电流。这归因于 MIL-101(Cr) 的结晶有序结构和大比表面积，以及 Pt NPs 的高导电性。差分脉冲伏安法 (DPV) 显示该传感器具有较宽的线性范围 (0.5-162 μM)、较低的检测限 (0.42 μM) 和较高的选择性。它可用于在分别为 0.13、0.28、0.68 和 1.05 V（相对于 Ag/AgCl）的工作电位下同时测定多巴胺、尿酸、黄嘌呤和次黄嘌呤，并定量测定加标血清样品中的黄嘌呤。
