Myint Aung S, Rieders Brandon, Tashkandi Mohammed, Borum Marie L, Koh Joyce M, Stephen Sindu, Doman David B
Dr Myint, Dr Rieders, and Dr Tashkandi are gastroenterology fellows in the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center and are affiliated with Medical Faculty Associates, both in Washington, DC. Dr Borum is a professor of medicine at George Washington University School of Medicine in Washington, DC; director of the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center; and is affiliated with Medical Faculty Associates. Dr Koh and Dr Stephen are in private practice in Silver Spring, Maryland. Dr Doman is a clinical professor of medicine at George Washington University School of Medicine and is in private practice in Silver Spring, Maryland.
Gastroenterol Hepatol (N Y). 2018 Nov;14(11):639-645.
Gastroparesis is a complex, debilitating dysmotility disorder with challenging symptom management. A diagnosis of gastroparesis is based on objectively delayed gastric emptying in the absence of mechanical obstruction. Given the limited efficacy of treatment options and serious side effects, significant research continues for therapeutic options for gastroparesis. Promising investigational pharmacologic therapies include relamorelin, prucalopride, and aprepitant. A novel endoscopic therapy is gastric peroral endoscopic pyloromyotomy, which is associated with improved gastric emptying. This article reviews both current and emerging therapeutic options for gastroparesis, including dietary modification and pharmacologic, electrical stimulation, endoscopic, and surgical therapies. Further research and novel treatment options are needed to address the substantial morbidity of gastroparesis.
胃轻瘫是一种复杂的、使人衰弱的动力障碍性疾病，其症状管理颇具挑战性。胃轻瘫的诊断基于在无机械性梗阻的情况下胃排空客观延迟。鉴于现有治疗方案疗效有限且副作用严重，针对胃轻瘫治疗方案的大量研究仍在继续。有前景的研究性药物疗法包括瑞莫瑞林、普芦卡必利和阿瑞匹坦。一种新型内镜治疗方法是经口内镜幽门肌切开术，它与胃排空改善相关。本文综述了胃轻瘫的现有和新兴治疗方案，包括饮食调整以及药物、电刺激、内镜和手术治疗。需要进一步研究和新的治疗选择来解决胃轻瘫的严重发病率问题。
