Section of Experimental Oncology & Immunology, Department of Molecular & Translational Medicine (DMTM), University of Brescia, Brescia 25123, Italy.
Section of Biotechnology, Department of Molecular & Translational Medicine (DMTM), University of Brescia, Brescia 25123, Italy.
Future Med Chem. 2018 Dec;10(24):2835-2854. doi: 10.4155/fmc-2018-0298. Epub 2018 Dec 12.
Sialic acid is associated with glycoproteins and gangliosides of eukaryotic cells. It regulates various molecular interactions, being implicated in inflammation and cancer, where its expression is regulated by sialyltransferases and sialidases. Angiogenesis, the formation of new capillaries, takes place during inflammation and cancer, and represents the outcome of several interactions occurring at the endothelial surface among angiogenic growth factors, inhibitors, receptors, gangliosides and cell-adhesion molecules. Here, we elaborate on the evidences that many structures involved in angiogenesis are sialylated and that their interactions depend on sialic acid with implications in angiogenesis itself, inflammation and cancer. We also discuss the possibility to exploit sialic acid as a target for the development of novel antiangiogenic drugs.
唾液酸与真核细胞的糖蛋白和神经节苷脂有关。它调节各种分子相互作用，与炎症和癌症有关，其表达受唾液酸转移酶和唾液酸酶调节。血管生成，即新毛细血管的形成，发生在炎症和癌症期间，是发生在血管生成生长因子、抑制剂、受体、神经节苷脂和细胞黏附分子之间的内皮表面的几种相互作用的结果。在这里，我们详细阐述了许多参与血管生成的结构都被唾液酸化的证据，以及它们的相互作用依赖于唾液酸，这对血管生成本身、炎症和癌症都有影响。我们还讨论了将唾液酸作为开发新型抗血管生成药物的靶点的可能性。
