先天性失明对精神分裂症和其他精神病有保护作用。一项全人群研究。
Congenital blindness is protective for schizophrenia and other psychotic illness. A whole-population study.
机构信息
Neuropsychiatric Epidemiology Research Unit, Division of Psychiatry, Faculty of Health and Medical Sciences, University of Western Australia, Medical Research Foundation Building, Rear 50, Murray Street, Perth 6000, Australia; Centre for Clinical Research in Neuropsychiatry, Division of Psychiatry, Faculty of Health and Medical Sciences, University of Western Australia, Medical Research Foundation Building, Rear 50, Murray Street, Perth 6000, Australia.
Centre for Clinical Research in Neuropsychiatry, Division of Psychiatry, Faculty of Health and Medical Sciences, University of Western Australia, Medical Research Foundation Building, Rear 50, Murray Street, Perth 6000, Australia.
出版信息
Schizophr Res. 2018 Dec;202:414-416. doi: 10.1016/j.schres.2018.06.061. Epub 2018 Jul 7.
Congenital/early blindness is reportedly protective against schizophrenia. Using a whole-population cohort of 467,945 children born in Western Australia between 1980 and 2001, we examined prevalence of schizophrenia and psychotic illness in individuals with congenital/early blindness. Overall, 1870 children developed schizophrenia (0.4%) while 9120 developed a psychotic illness (1.9%). None of the 66 children with cortical blindness developed schizophrenia or psychotic illness. Eight of the 613 children with peripheral blindness developed a psychotic illness other than schizophrenia and fewer had developed schizophrenia. Our results support findings from small case studies that congenital/early cortical but not peripheral blindness is protective against schizophrenia.
据报道，先天性/早期失明对精神分裂症有保护作用。我们使用了 1980 年至 2001 年间在澳大利亚西部出生的 467945 名儿童的全人群队列，研究了先天性/早期失明个体中精神分裂症和精神病的患病率。总体而言，1870 名儿童患有精神分裂症（0.4%），9120 名儿童患有精神病（1.9%）。66 名皮质盲儿童均未患精神分裂症或精神病。613 名周边盲儿童中有 8 名患有除精神分裂症以外的精神病，且较少患有精神分裂症。我们的研究结果支持从小样本病例研究中得出的发现，即先天性/早期皮质盲而非周边盲对精神分裂症有保护作用。
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