Centre de Neurophysique, Physiologie, et Pathologie, UMR 8119 CNRS/Université Paris Descartes , Paris , France.
Physiology, Northwestern University Feinberg School of Medicine , Chicago, Illinois.
Physiology (Bethesda). 2019 Jan 1;34(1):5-13. doi: 10.1152/physiol.00021.2018.
Appropriate scaling of motor output from mouse to humans is essential. The motoneurons that generate all motor output are, however, very different in rodents compared with humans, being smaller and much more excitable. In contrast, feline motoneurons are more similar to those in humans. These scaling differences need to be taken into account for the use of rodents for translational studies of motor output.
适当调整从老鼠到人类的运动输出是至关重要的。然而，产生所有运动输出的运动神经元在啮齿动物和人类之间有很大的不同，啮齿动物的运动神经元更小，兴奋性也更高。相比之下，猫科动物的运动神经元更类似于人类的运动神经元。在将啮齿动物用于运动输出的转化研究时，需要考虑这些比例差异。
