• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于生物信息学的乳腺癌和妇科癌症药物再利用方法：基因定位共同枢纽基因和药物。

Bioinformatics Based Drug Repurposing Approach for Breast and Gynecological Cancers: Genes Address Common Hub Genes and Drugs.

作者信息

Ayna Duran Gizem

机构信息

Department of Biomedical Engineering, Faculty of Engineering, İzmir University of Economics, İzmir, Turkey.

出版信息

Eur J Breast Health. 2025 Jan 1;21(1):63-73. doi: 10.4274/ejbh.galenos.2024.2024-11-2.

DOI:10.4274/ejbh.galenos.2024.2024-11-2
PMID:39744927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11706122/
Abstract

OBJECTIVE

The prevalence of breast cancer and gynaecological cancers is high, and these cancer types can occur consecutively as secondary cancers. The aim of our study is to determine the genes commonly expressed in these cancers and to identify the common hub genes and drug components.

MATERIALS AND METHODS

Gene intensity values of breast cancer, gynaecological cancers such as cervical, ovarian and endometrial cancers were used from the Gene Expression Omnibus database Affymetrix Human Genome U133 Plus 2.0 Array project. Using the linear modelling method included in the R LIMMA package, genes that differ between healthy individuals and cancer patients were identified. Hub genes were determined using cytoHubba in Cytoscape program. "ShinyGo 0.80" tool was used to determine the disease-specific biological KEGG pathways. Drug.MATADOR from the ShinyGo 0.80 tool was used to predict drug-target relationships.

RESULTS

The RecQ Like Helicase 4 and genes were found to be similarly expressed in breast cancer and gynaecological cancers. Upon KEGG pathway analyses with hub genes, Drug.MATADOR analysis with hub genes related to cancer related pathways was performed. We have determined these gene/drug interactions: NBN (targeted by Hydroxyurea), EP300 (targeted by Acetylcarnitine) and MAPK14 (targeted by Salicylate and Dibutyryl cyclic AMP).

CONCLUSION

The drugs associated with hub genes determined in our study are not routinely used in cancer treatment. Our study offers the opportunity to identify the target genes of drugs used in breast and gynaecological cancers with the drug repurposing approach.

摘要

目的

乳腺癌和妇科癌症的患病率很高，并且这些癌症类型可作为继发性癌症连续发生。我们研究的目的是确定这些癌症中共同表达的基因，并识别共同的枢纽基因和药物成分。

材料与方法

使用基因表达综合数据库Affymetrix人类基因组U133 Plus 2.0阵列项目中乳腺癌、妇科癌症（如宫颈癌、卵巢癌和子宫内膜癌）的基因强度值。使用R LIMMA软件包中包含的线性建模方法，确定健康个体和癌症患者之间存在差异的基因。使用Cytoscape程序中的cytoHubba确定枢纽基因。使用“ShinyGo 0.80”工具确定疾病特异性的生物KEGG通路。使用ShinyGo 0.80工具中的Drug.MATADOR预测药物-靶点关系。

结果

发现类RecQ解旋酶4基因在乳腺癌和妇科癌症中表达相似。在用枢纽基因进行KEGG通路分析后，对与癌症相关通路相关的枢纽基因进行了Drug.MATADOR分析。我们确定了这些基因/药物相互作用：NBN（由羟基脲靶向）、EP300（由乙酰肉碱靶向）和MAPK14（由水杨酸盐和二丁酰环磷腺苷靶向）。

结论

我们研究中确定的与枢纽基因相关的药物在癌症治疗中并非常规使用。我们的研究提供了一个机会，通过药物重新利用方法来识别用于乳腺癌和妇科癌症治疗的药物的靶基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693a/11706122/f244ecdc90a1/EurJBreastHealth-21-63-figure-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693a/11706122/42aba36f939c/EurJBreastHealth-21-63-figure-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693a/11706122/c30e831ebbe4/EurJBreastHealth-21-63-figure-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693a/11706122/03dd70a7ca11/EurJBreastHealth-21-63-figure-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693a/11706122/796b4a65e52e/EurJBreastHealth-21-63-figure-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693a/11706122/f244ecdc90a1/EurJBreastHealth-21-63-figure-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693a/11706122/42aba36f939c/EurJBreastHealth-21-63-figure-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693a/11706122/c30e831ebbe4/EurJBreastHealth-21-63-figure-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693a/11706122/03dd70a7ca11/EurJBreastHealth-21-63-figure-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693a/11706122/796b4a65e52e/EurJBreastHealth-21-63-figure-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693a/11706122/f244ecdc90a1/EurJBreastHealth-21-63-figure-5.jpg

相似文献

1
Bioinformatics Based Drug Repurposing Approach for Breast and Gynecological Cancers: Genes Address Common Hub Genes and Drugs.基于生物信息学的乳腺癌和妇科癌症药物再利用方法：基因定位共同枢纽基因和药物。
Eur J Breast Health. 2025 Jan 1;21(1):63-73. doi: 10.4274/ejbh.galenos.2024.2024-11-2.
2
Integrated bioinformatics analysis for the screening of hub genes and therapeutic drugs in ovarian cancer.卵巢癌中枢纽基因和治疗药物的筛选的综合生物信息学分析。
J Ovarian Res. 2020 Jan 27;13(1):10. doi: 10.1186/s13048-020-0613-2.
3
Integrated bioinformatics analysis to identify 15 hub genes in breast cancer.综合生物信息学分析以鉴定乳腺癌中的15个关键基因。
Oncol Lett. 2019 Aug;18(2):1023-1034. doi: 10.3892/ol.2019.10411. Epub 2019 May 30.
4
A bioinformatics analysis of the clinicopathological and prognostic significance of mRNA expression in gynecological cancers.mRNA 表达在妇科癌症中的临床病理和预后意义的生物信息学分析。
J Obstet Gynaecol. 2023 Dec;43(1):2216280. doi: 10.1080/01443615.2023.2216280.
5
Clear Cell Renal Cell Carcinoma: A Comprehensive in silico Study in Searching for Therapeutic Targets.透明细胞肾细胞癌：寻找治疗靶点的综合计算研究。
Kidney Blood Press Res. 2023;48(1):135-150. doi: 10.1159/000529861. Epub 2023 Feb 28.
6
Identification of breast cancer hub genes and analysis of prognostic values using integrated bioinformatics analysis.基于综合生物信息学分析鉴定乳腺癌枢纽基因并分析其预后价值。
Cancer Biomark. 2017 Dec 12;21(1):373-381. doi: 10.3233/CBM-170550.
7
Eight hub genes as potential biomarkers for breast cancer diagnosis and prognosis: A TCGA-based study.八个作为乳腺癌诊断和预后潜在生物标志物的核心基因：一项基于TCGA的研究。
World J Clin Oncol. 2022 Aug 24;13(8):675-688. doi: 10.5306/wjco.v13.i8.675.
8
Bioinformatics and Systems Biology Approach to Identify the Pathogenetic Link Between Psoriasis and Cardiovascular Disease.生物信息学与系统生物学方法用于识别银屑病与心血管疾病之间的致病联系。
Clin Cosmet Investig Dermatol. 2023 Aug 22;16:2283-2295. doi: 10.2147/CCID.S421193. eCollection 2023.
9
Identification of Hub Genes and Pathways of Triple Negative Breast Cancer by Expression Profiles Analysis.通过表达谱分析鉴定三阴性乳腺癌的枢纽基因和通路
Cancer Manag Res. 2021 Mar 1;13:2095-2104. doi: 10.2147/CMAR.S295951. eCollection 2021.
10
Identification of Tissue-Specific Expressed Hub Genes and Potential Drugs in Rheumatoid Arthritis Using Bioinformatics Analysis.利用生物信息学分析鉴定类风湿关节炎中组织特异性表达的枢纽基因和潜在药物
Front Genet. 2022 Mar 18;13:855557. doi: 10.3389/fgene.2022.855557. eCollection 2022.

本文引用的文献

1
The Ubiquitin-Conjugating Enzyme E2 O (UBE2O) and Its Therapeutic Potential in Human Leukemias and Solid Tumors.泛素结合酶E2 O（UBE2O）及其在人类白血病和实体瘤中的治疗潜力。
Cancers (Basel). 2024 Sep 3;16(17):3064. doi: 10.3390/cancers16173064.
2
Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches.泛素化和去泛素化在癌症中的作用：从机制到新的治疗方法。
Mol Cancer. 2024 Jul 25;23(1):148. doi: 10.1186/s12943-024-02046-3.
3
NAP1L1 Promotes Endometrial Cancer Progression via EP300-Mediated DDX5 Promoter Acetylation.
NAP1L1 通过 EP300 介导的 DDX5 启动子乙酰化促进子宫内膜癌进展。
Mol Cancer Res. 2024 Nov 1;22(11):1011-1021. doi: 10.1158/1541-7786.MCR-23-0871.
4
Cellular senescence: a double-edged sword in cancer therapy.细胞衰老：癌症治疗中的一把双刃剑。
Front Oncol. 2023 Sep 12;13:1189015. doi: 10.3389/fonc.2023.1189015. eCollection 2023.
5
Investigating the relationship between breast and gynecological cancers and infertility and its treatments: a case-control study.探讨乳腺癌和妇科癌症与不孕及其治疗之间的关系：病例对照研究。
Eur J Cancer Prev. 2023 Nov 1;32(6):600-607. doi: 10.1097/CEJ.0000000000000815. Epub 2023 May 22.
6
FAM family gene prediction model reveals heterogeneity, stemness and immune microenvironment of UCEC.FAM家族基因预测模型揭示了子宫内膜癌的异质性、干性和免疫微环境。
Front Mol Biosci. 2023 May 19;10:1200335. doi: 10.3389/fmolb.2023.1200335. eCollection 2023.
7
Global trends and forecasts of breast cancer incidence and deaths.全球乳腺癌发病与死亡趋势及预测。
Sci Data. 2023 May 27;10(1):334. doi: 10.1038/s41597-023-02253-5.
8
Profiling of immune responses by lactate modulation in cervical cancer reveals key features driving clinical outcome.通过乳酸调节对宫颈癌免疫反应进行分析揭示了驱动临床结果的关键特征。
Heliyon. 2023 Mar 25;9(4):e14896. doi: 10.1016/j.heliyon.2023.e14896. eCollection 2023 Apr.
9
Importance of Germline and Somatic Alterations in Human , , and Genes Coding for MRN Complex.MRN 复合物编码基因 、 和 中胚层和体细胞改变的重要性。
Int J Mol Sci. 2023 Mar 15;24(6):5612. doi: 10.3390/ijms24065612.
10
Expression of DDB1 is associated with subtypes of epithelial ovarian cancer and predicts clinical outcomes.DDB1 的表达与上皮性卵巢癌的亚型相关，并预测临床结局。
Tissue Cell. 2023 Jun;82:102072. doi: 10.1016/j.tice.2023.102072. Epub 2023 Mar 15.