Department of Immunology, Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Cell Host Microbe. 2018 Dec 12;24(6):755-757. doi: 10.1016/j.chom.2018.11.012.
Gut fungal dysbiosis exacerbates colitis and lung allergy. In recent studies published in Science (Leonardi et al., 2018) and Cell Host & Microbe (Li et al., 2018), gut-resident CXCR1 mononuclear phagocytes were found to mediate crosstalk between intestinal fungi and systemic immunity along the lung-gut axis during homeostasis and inflammation.
肠道真菌失调会加重结肠炎和肺部过敏。在最近发表于《科学》（Leonardi 等人，2018 年）和《细胞-宿主与微生物》（Li 等人，2018 年）的研究中，人们发现肠道驻留的 CXCR1 单核吞噬细胞在肠道真菌和系统性免疫之间沿着肺-肠轴在稳态和炎症期间进行串扰。
