Shin Hanna, Reiner David J
Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.
College of Medicine, Texas A & M University, Houston, TX 77030, USA.
J Dev Biol. 2018 Dec 11;6(4):30. doi: 10.3390/jdb6040030.
EGF, emitted by the Anchor Cell, patterns six equipotent vulval precursor cells to assume a precise array of three cell fates with high fidelity. A group of core and modulatory signaling cascades forms a signaling network that demonstrates plasticity during the transition from naïve to terminally differentiated cells. In this review, we summarize the history of classical developmental manipulations and molecular genetics experiments that led to our understanding of the signals governing this process, and discuss principles of signal transduction and developmental biology that have emerged from these studies.
由锚定细胞分泌的表皮生长因子（EGF）使六个等潜能的外阴前体细胞形成具有高保真度的三种细胞命运的精确排列。一组核心和调节信号级联形成一个信号网络，该网络在从幼稚细胞向终末分化细胞转变的过程中表现出可塑性。在这篇综述中，我们总结了经典发育操作和分子遗传学实验的历史，这些实验使我们了解了控制这一过程的信号，并讨论了从这些研究中得出的信号转导和发育生物学原理。
