聚焦超声与阿尔茨海默病：一项系统综述
Focused ultrasound and Alzheimer's disease A systematic review.
作者信息
Souza Rodrigo Marmo da Costa E, da Silva Inaê Carolline Silveira, Delgado Anna Beatriz Temoteo, da Silva Pedro Hugo Vieira, Costa Victor Ribeiro Xavier
机构信息
Neurosurgeon. Departamento de Psicologia, Programa de Neurociências Cognitiva e do Comportamento, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil.
Departamento de Medicina, Liga de Neurologia e Neurocirurgia Funcional da Paraíba, Cabedelo, PB, Brazil.
出版信息
Dement Neuropsychol. 2018 Oct-Dec;12(4):353-359. doi: 10.1590/1980-57642018dn12-040003.
UNLABELLED
Alzheimer's disease (AD) affects millions of people, however, there is still no effective treatment. The use of focused ultrasound with microbubbles (FUS-MB) for the opening of the blood-brain barrier has been recently studied and may become a promising therapeutic target.
OBJECTIVE
To discuss the use of FUS-MB for the treatment of AD and to present some of the techniques used.
METHODS
A systematic review was performed of MEDLINE/PubMed and Biblioteca Virtual em Saúde (BVS) services, using the keywords: focused ultrasound, Alzheimer, amyloid-b. Original articles were included in the study; studies that did not focus on Alzheimer's treatment were excluded.
RESULTS
Fifteen original studies were selected. Preclinical trials were able to reduce amyloid-b plaques and tau phosphorylation, improving cognitive performance in AD animals.
CONCLUSION
The results are very promising, but the therapy still requires maturation. Further studies are needed to systematize all the techniques used and their effects in order to enable use in humans.
未标注
阿尔茨海默病（AD）影响着数百万人，但目前仍没有有效的治疗方法。最近对聚焦超声联合微泡（FUS-MB）打开血脑屏障的应用进行了研究，这可能成为一个有前景的治疗靶点。
目的
探讨FUS-MB在AD治疗中的应用，并介绍一些所使用的技术。
方法
对MEDLINE/PubMed和虚拟健康图书馆（BVS）服务进行系统综述，使用关键词：聚焦超声、阿尔茨海默病、淀粉样蛋白-β。纳入研究中的原创文章；排除未专注于阿尔茨海默病治疗的研究。
结果
选择了15项原创研究。临床前试验能够减少淀粉样蛋白-β斑块和tau蛋白磷酸化，改善AD动物的认知表现。
结论
结果非常有前景，但该疗法仍需完善。需要进一步研究以系统化所有使用的技术及其效果，以便能够应用于人类。
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