[弯曲杆菌对两类新型β-内酰胺类药物的敏感性]
[Sensitivity of Campylobacter to 2 new groups of beta-lactams].
作者信息
Belbouri A, Novo Y, Megraud F
机构信息
Laboratoire de Bacteriologie, Hôpital des Enfants, Bordeaux.
出版信息
Pathol Biol (Paris). 1988 Jun;36(5 Pt 2):675-7.
One hundred strains of Campylobacter (44 C. jejuni, 34 C. coli, and 22 C. fetus ssp. fetus) were tested with two new groups of beta-lactams:monobactams (azthreonam and carumonam) and carbapenem (imipenem). MICs were determined by using an agar dilution technique. The monobactams were not effective against Campylobacter species. In contrast, imipenem showed a high activity (MIC 90, 0.25 mg/l). Clinical trials will indicate if this compound can be used in the therapy of severe Campylobacter infections.
用两组新型β-内酰胺类药物（单环β-内酰胺类药物氨曲南和卡芦莫南以及碳青霉烯类药物亚胺培南）对100株弯曲杆菌（44株空肠弯曲菌、34株结肠弯曲菌和22株胎儿弯曲菌胎儿亚种）进行了测试。采用琼脂稀释技术测定最低抑菌浓度（MIC）。单环β-内酰胺类药物对弯曲杆菌属无效。相比之下，亚胺培南显示出高活性（MIC90为0.25mg/L）。临床试验将表明该化合物是否可用于治疗严重的弯曲杆菌感染。
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