Belbouri A, Novo Y, Megraud F
Laboratoire de Bacteriologie, Hôpital des Enfants, Bordeaux.
Pathol Biol (Paris). 1988 Jun;36(5 Pt 2):675-7.
One hundred strains of Campylobacter (44 C. jejuni, 34 C. coli, and 22 C. fetus ssp. fetus) were tested with two new groups of beta-lactams:monobactams (azthreonam and carumonam) and carbapenem (imipenem). MICs were determined by using an agar dilution technique. The monobactams were not effective against Campylobacter species. In contrast, imipenem showed a high activity (MIC 90, 0.25 mg/l). Clinical trials will indicate if this compound can be used in the therapy of severe Campylobacter infections.
用两组新型β-内酰胺类药物(单环β-内酰胺类药物氨曲南和卡芦莫南以及碳青霉烯类药物亚胺培南)对100株弯曲杆菌(44株空肠弯曲菌、34株结肠弯曲菌和22株胎儿弯曲菌胎儿亚种)进行了测试。采用琼脂稀释技术测定最低抑菌浓度(MIC)。单环β-内酰胺类药物对弯曲杆菌属无效。相比之下,亚胺培南显示出高活性(MIC90为0.25mg/L)。临床试验将表明该化合物是否可用于治疗严重的弯曲杆菌感染。