头孢洛扎-他唑巴坦对西班牙一家医院耐多药和广泛耐药铜绿假单胞菌临床分离株的抗菌活性。
Antimicrobial activity of ceftolozane-tazobactam against multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa clinical isolates from a Spanish hospital.
作者信息
López-Calleja A I, Morilla Morales E, Nuñez Medina R, Fernández Esgueva M, Sahagún Pareja J, García-Lechuz Moya J M, Ferrer Cerón I, Viñuelas Bayon J, Rezusta López A
机构信息
Ana Isabel López-Calleja, Servicio de Microbiología, Hospital Universitario Miguel Servet. IIS Aragón. 3ª planta Edificio de Consultas Externas - c/ Padre Arrupe s/n, 50009 Zaragoza, Spain.
出版信息
Rev Esp Quimioter. 2019 Feb;32(1):68-72. Epub 2018 Dec 14.
OBJECTIVE
Our objective was to evaluate the in vitro activity of ceftolozane-tazobactam against multidrug resistant (MDR) and extensively drug-resistant (XDR) non metallo-β-lactamase producing Pseudomonas aeruginosa clinical isolates at Hospital Universitario Miguel Servet (Zaragoza, Spain) from February 2016 to October 2017.
METHODS
We evaluated the in vitro activity of ceftolozane-tazobactam and other antipseudomonal antibiotics against 12 MDR and 117 XDR non metallo-β-lactamase producing P. aeruginosa isolates. Ceftolozane-tazobactam minimal inhibitory concentrations (MICs) were determined by MIC gradient diffusion test strip.
RESULTS
Among the 129 MDR/XDR isolates included, 119 (92.2%) were susceptible to ceftolozane-tazobactam, and ten (7.8%) were resistant. MIC50 was 2 mg/L, and MIC90 4 mg/L. Ceftolozane-tazobactam was the second most active antibiotic after colistin, overtaking amikacin.
CONCLUSIONS
Ceftolozane-tazobactam is a valuable treatment option for MDR and XDR P. aeruginosa infections in our setting.
目的
我们的目的是评估2016年2月至2017年10月在西班牙萨拉戈萨米格尔·塞维特大学医院，头孢他啶-阿维巴坦对多重耐药（MDR）和广泛耐药（XDR）、不产金属β-内酰胺酶的铜绿假单胞菌临床分离株的体外活性。
方法
我们评估了头孢他啶-阿维巴坦和其他抗假单胞菌抗生素对12株MDR和117株XDR、不产金属β-内酰胺酶的铜绿假单胞菌分离株的体外活性。通过MIC梯度扩散试验条测定头孢他啶-阿维巴坦的最低抑菌浓度（MICs）。
结果
在纳入的129株MDR/XDR分离株中，119株（92.2%）对头孢他啶-阿维巴坦敏感，10株（7.8%）耐药。MIC50为2mg/L，MIC90为4mg/L。头孢他啶-阿维巴坦是继黏菌素之后活性第二高的抗生素，超过了阿米卡星。
结论
在我们的研究环境中，头孢他啶-阿维巴坦是治疗MDR和XDR铜绿假单胞菌感染的一个有价值的治疗选择。
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