Vaccine Research Center, University of Tampere, Tampere, Finland.
Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
Acta Paediatr. 2019 Jul;108(7):1338-1344. doi: 10.1111/apa.14690. Epub 2019 Jan 22.
This study examined the prevalence and clinical significance of the sapovirus infection in children with acute gastroenteritis before and after the introduction of the rotavirus vaccination in Finland in 2009.
We collected 1437 stool samples from children under 16 years during three prospective hospital-based surveillance studies of acute gastroenteritis at Tampere University Hospital, Finland. The children were seen in the emergency department (47%) or admitted to the ward (53%). Sapovirus findings from 2006 to 2008 (n = 759), before national immunisation, were compared to 2009-2011 (n = 330) and 2012-2014 (n = 348), after the national programme was launched.
The overall incidence of the sapovirus was 3.3%. It was present in 1.4% of acute gastroenteritis cases in 2006-2008 and 5.5% in the post-vaccination years, but the absolute number did not increase. Sapoviruses mainly occurred in the winter and spring, but did not follow the prevalence of the norovirus or rotavirus. Sapovirus GI.1 and GII.1 were the most common genotypes, but the predominant strain was different each season. Many sapovirus lineages appeared during multiple seasons and reappeared later.
The sapovirus was uncommonly and sporadically detected in children seen in the hospital for acute gastroenteritis, and its relative role increased after national immunisation was introduced.
本研究旨在探讨 2009 年芬兰引入轮状病毒疫苗前后，急性肠胃炎患儿中诺如病毒感染的流行情况及临床意义。
我们收集了芬兰坦佩雷大学医院进行的 3 项急性肠胃炎前瞻性医院监测研究中 16 岁以下儿童的 1437 份粪便样本。这些儿童在急诊部（47%）或病房（53%）就诊。2006 年至 2008 年（n=759）在国家免疫接种前，与 2009-2011 年（n=330）和 2012-2014 年（n=348）进行比较，后者在全国计划启动后。
轮状病毒的总体发病率为 3.3%。2006-2008 年急性肠胃炎病例中有 1.4%存在轮状病毒，接种疫苗后为 5.5%，但绝对数量并未增加。轮状病毒主要发生在冬季和春季，但与诺如病毒或轮状病毒的流行情况不符。GI.1 和 GII.1 是最常见的基因型，但每个季节的主要毒株都不同。许多轮状病毒谱系在多个季节出现，并在以后再次出现。
在因急性肠胃炎就诊的住院儿童中，轮状病毒罕见且呈散发性检出，在国家免疫接种引入后，其相对作用增加。
