van Rhijn Norman, Bromley Michael
Manchester Fungal Infection Group, University of Manchester, Manchester M13 9PL, UK.
J Fungi (Basel). 2021 May 7;7(5):367. doi: 10.3390/jof7050367.
Human activities have significantly impacted the environment and are changing our climate in ways that will have major consequences for ourselves, and endanger animal, plant and microbial life on Earth. Rising global temperatures and pollution have been highlighted as potential drivers for increases in infectious diseases. Although infrequently highlighted, fungi are amongst the leading causes of infectious disease mortality, resulting in more than 1.5 million deaths every year. In this review we evaluate the evidence linking anthropomorphic impacts with changing epidemiology of fungal disease. We highlight how the geographic footprint of endemic mycosis has expanded, how populations susceptible to fungal infection and fungal allergy may increase and how climate change may select for pathogenic traits and indirectly contribute to the emergence of drug resistance.
人类活动已对环境产生了重大影响，正以各种方式改变我们的气候，这些变化将给我们自身带来重大后果，并危及地球上的动物、植物和微生物生命。全球气温上升和污染已被视为传染病增加的潜在驱动因素。尽管真菌很少被提及，但它却是导致传染病死亡的主要原因之一，每年造成超过150万人死亡。在本综述中，我们评估了将人为影响与真菌病流行病学变化联系起来的证据。我们强调了地方性真菌病的地理分布范围是如何扩大的，易受真菌感染和真菌过敏影响的人群可能如何增加，以及气候变化如何可能促使致病性状的出现并间接导致耐药性的产生。
