Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Diabetes Care. 2019 Feb;42(2):327-330. doi: 10.2337/dc18-1302. Epub 2018 Dec 14.
To assess the prevalence of cerebral small-vessel disease (SVD) in subjects with type 1 diabetes compared with healthy control subjects and to characterize the diabetes-related factors associated with SVD.
This substudy was cross-sectional in design and included 191 participants with type 1 diabetes and median age 40.0 years (interquartile range 33.0-45.1) and 30 healthy age- and sex-matched control subjects. All participants underwent clinical investigation and brain MRIs, assessed for cerebral SVD.
Cerebral SVD was more common in participants with type 1 diabetes than in healthy control subjects: any marker 35% vs. 10% ( = 0.005), cerebral microbleeds (CMBs) 24% vs. 3.3% ( = 0.008), white matter hyperintensities 17% vs. 6.7% ( = 0.182), and lacunes 2.1% vs. 0% ( = 1.000). Presence of CMBs was independently associated with systolic blood pressure (odds ratio 1.03 [95% CI 1.00-1.05], = 0.035).
Cerebral SVD, CMBs in particular, is more common in young people with type 1 diabetes compared with healthy control subjects.
评估与健康对照组相比，1 型糖尿病患者脑小血管疾病 (SVD) 的患病率，并描述与 SVD 相关的糖尿病相关因素。
本研究为横断面研究，纳入了 191 名年龄中位数为 40.0 岁（四分位间距 33.0-45.1）的 1 型糖尿病患者和 30 名年龄和性别匹配的健康对照组参与者。所有参与者均接受了临床检查和脑部 MRI 检查，评估脑 SVD。
与健康对照组相比，1 型糖尿病患者的脑 SVD 更为常见：任何标志物 35%比 10%（=0.005），脑微出血（CMB）24%比 3.3%（=0.008），脑白质高信号 17%比 6.7%（=0.182），腔隙性梗死 2.1%比 0%（=1.000）。CMB 的存在与收缩压独立相关（优势比 1.03[95%CI 1.00-1.05]，=0.035）。
与健康对照组相比，年轻的 1 型糖尿病患者脑 SVD，特别是 CMBs，更为常见。
