Woodfield Julie, Hoeritzauer Ingrid, Jamjoom Aimun A B, Pronin Savva, Srikandarajah Nisaharan, Poon Michael, Roy Holly, Demetriades Andreas K, Sell Philip, Eames Niall, Statham Patrick F X
Department for Clinical Neurosciences, Western General Hospital, Edinburgh, UK.
Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
BMJ Open. 2018 Dec 14;8(12):e025230. doi: 10.1136/bmjopen-2018-025230.
Cauda equina syndrome (CES) is a potentially devastating condition caused by compression of the cauda equina nerve roots. This can result in bowel, bladder and sexual dysfunction plus lower limb weakness, numbness and pain. CES occurs infrequently, but has serious potential morbidity and medicolegal consequences. This study aims to identify and describe the presentation and management of patients with CES in the UK.
Understanding Cauda Equina Syndrome (UCES) is a prospective and collaborative multicentre cohort study of adult patients with confirmed CES managed at specialist spinal centres in the UK. Participants will be identified using neurosurgical and orthopaedic trainee networks to screen referrals to spinal centres. Details of presentation, investigations, management and service usage will be recorded. Both patient-reported and clinician-reported outcome measures will be assessed for 1 year after surgery. This will establish the incidence of CES, current investigation and management practices, and adherence to national standards of care. Outcomes will be stratified by clinical presentation and patient management. Accurate and up to date information about the presentation, management and outcome of patients with CES will inform standards of service design and delivery for this important but infrequent condition.
UCES received a favourable ethical opinion from the South East Scotland Research Ethics Committee 02 (Reference: 18/SS/0047; IRAS ID: 233515). All spinal centres managing patients with CES in the UK will be encouraged to participate in UCES. Study results will be published in medical journals and shared with local participating sites.
ISRCTN16828522; Pre-results.
马尾综合征（CES）是一种由马尾神经根受压引起的潜在破坏性疾病。这可能导致肠道、膀胱和性功能障碍，以及下肢无力、麻木和疼痛。CES并不常见，但具有严重的潜在发病率和法医学后果。本研究旨在识别和描述英国CES患者的临床表现及治疗情况。
了解马尾综合征（UCES）是一项针对在英国专科脊柱中心接受治疗的确诊CES成年患者的前瞻性协作多中心队列研究。将通过神经外科和骨科实习医生网络来识别参与者，以筛选转诊至脊柱中心的患者。记录临床表现、检查、治疗及服务使用的详细信息。术后1年将评估患者报告和临床医生报告的结局指标。这将确定CES的发病率、当前的检查和治疗方法，以及对国家标准治疗的依从性。结局将按临床表现和患者治疗情况进行分层。有关CES患者临床表现、治疗及结局的准确且最新的信息，将为这一重要但不常见疾病的服务设计和提供标准提供依据。
UCES获得了苏格兰东南部研究伦理委员会02的有利伦理意见（参考编号：18/SS/0047；IRAS识别号：233515）。将鼓励英国所有治疗CES患者的脊柱中心参与UCES。研究结果将发表在医学期刊上，并与当地参与研究的机构分享。
ISRCTN16828522；预结果。
