Program in Personalized and Genomic Medicine, and Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
Program in Personalized and Genomic Medicine, and Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.
J Clin Lipidol. 2019 Jan-Feb;13(1):109-114. doi: 10.1016/j.jacl.2018.11.006. Epub 2018 Nov 20.
Postprandial lipemia (PPL), defined as a prolonged or elevated rise in triglycerides that accompanies fat feeding, is a significant risk factor for coronary heart disease and associated comorbidities. The impact of PPL on coronary heart disease risk is underscored by the preponderance of each day spent in the postprandial state.
In this study, we evaluated cross-sectionally the association between usual (ie, noninterventional) physical activity and the 6-hour triglyceride response to a standardized high-fat meal.
The high-fat meal intervention was carried out in 671 apparently healthy individuals as part of the Heredity and Phenotype Intervention Heart Study. Triglyceride levels were measured in the fasting state and during 6 hours after administration of a standardized fat challenge. We defined PPL response as the triglyceride area under the fat load curve (AUC) and measured physical activity using accelerometers that were worn continuously over a 7-day period.
Physical activity levels decreased with increasing age and were higher in men than women (both P < .001). The triglyceride AUC increased with increasing age in both men and women (both P < .001) and was also higher in men than in women (age-adjusted P = 9.2 × 10). Higher physical activity levels were associated with a lower triglyceride AUC (P = .003), adjusting for age, sex, body mass index, and fasting low-density lipoprotein.
These results suggest that the protective benefits of physical activity on cardiovascular health may operate, at least in part, through reduction of the PPL triglyceride response.
餐后血脂升高（PPL）定义为进食脂肪后甘油三酯持续或升高，是冠心病及相关合并症的重要危险因素。由于每天大部分时间处于餐后状态，PPL 对冠心病风险的影响更为显著。
本研究通过横断面研究评估了通常（即非干预性）体力活动与标准化高脂肪餐后 6 小时甘油三酯反应之间的关系。
作为遗传性和表型干预心脏研究的一部分，671 名健康个体参与了高脂肪餐干预。在给予标准化脂肪负荷后，分别在空腹状态和 6 小时测量甘油三酯水平。我们将 PPL 反应定义为脂肪负荷曲线下的甘油三酯面积（AUC），并使用连续佩戴 7 天的加速度计测量体力活动。
体力活动水平随年龄的增加而降低，男性高于女性（均 P <.001）。男女的甘油三酯 AUC 均随年龄的增加而增加（均 P <.001），且男性高于女性（年龄调整后 P = 9.2 × 10）。较高的体力活动水平与较低的甘油三酯 AUC 相关（P =.003），调整了年龄、性别、体重指数和空腹低密度脂蛋白。
这些结果表明，体力活动对心血管健康的保护作用可能部分通过降低 PPL 甘油三酯反应来实现。
