单链二价阳离子吡啶基表面活性剂的自组装和生物学性质。
Self-assembling and biological properties of single-chain dicationic pyridinium-based surfactants.
机构信息
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., Kazan, 420088, Russia; Kazan National Research Technological University, 68 K. Marks str., Kazan, 420015, Russia.
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., Kazan, 420088, Russia; Kazan National Research Technological University, 68 K. Marks str., Kazan, 420015, Russia.
出版信息
Colloids Surf B Biointerfaces. 2019 Mar 1;175:351-357. doi: 10.1016/j.colsurfb.2018.12.010. Epub 2018 Dec 6.
In this work, the dicationic surfactants containing viologen and vinylbipyridinium moieties and hexadecyl chains were synthesized, and their aggregation behavior in water solutions was investigated by surface tension, conductivity measurements, hydrophobic probe solubilization, dynamic light scattering and electrophoretic measurements. Effect of UV-light on cis-trans isomerism of vinylbipyridinium derivative was determined. Antimicrobial activity and the influence of these surfactants on cell viability depended on the concentration and type of surfactant used. The results obtained established the structure-property (physicochemical properties and biological activity) relationship of the surfactant molecule namely the primary role of pyridinium head group structure.
在这项工作中，合成了含有二价阳离子基团和乙烯基联吡啶基团以及十六烷基链的二价阳离子表面活性剂，并通过表面张力、电导率测量、疏水性探针增溶、动态光散射和电泳测量研究了它们在水溶液中的聚集行为。测定了 UV 光对乙烯基联吡啶衍生物顺反异构的影响。这些表面活性剂的抗菌活性和对细胞活力的影响取决于所用表面活性剂的浓度和类型。所获得的结果确立了表面活性剂分子的结构-性质（物理化学性质和生物活性）关系，即吡啶鎓头基结构的主要作用。
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