College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, Jiangsu, People's Republic of China.
Anhui Science and Technology University, No. 1501 Mount Huangshan Avenue, Bengbu, 233100, Anhui, People's Republic of China.
Inflammation. 2019 Jun;42(3):937-945. doi: 10.1007/s10753-018-0948-7.
Oxidative stress and inflammation play an important role in the chronic kidney disease associated with obesity. Resveratrol (RSV) has been reported to exhibit a wide range of biological activities including antioxidant and anti-inflammatory properties. The objective of the present study was to investigate the effects of RSV on renal inflammation and oxidative stress in obese mice induced by high-fat diet. Male C57BL/6 mice were induced to have nephropathy associated obesity by high-fat diet for 12 weeks. After 8 weeks of feeding, oral supplementation with 100 mg RSV/kg body weight/day was applied with the high-fat-diet feeding for another 4 weeks. The results showed that RSV treatment protected against renal damage induced by high-fat diet, as evidenced by the decreased serum creatinine and urea nitrogen levels, alleviation of glomerular damage, and tubular vacuolization. In addition, RSV enhanced the antioxidant enzyme activity; improved the expression of genes related to inflammation; and decreased the malondialdehyde, tumor necrosis factor-α, and interleukin-6 concentrations in the kidney of high-fat-diet mice. In conclusion, RSV could alleviate renal damage in obese mice induced by high-fat diet via suppressing inflammation and oxidative stress.
氧化应激和炎症在肥胖相关的慢性肾脏病中起着重要作用。白藜芦醇（RSV）已被报道具有广泛的生物学活性，包括抗氧化和抗炎特性。本研究的目的是探讨 RSV 对高脂肪饮食诱导肥胖小鼠肾脏炎症和氧化应激的影响。雄性 C57BL/6 小鼠用高脂肪饮食喂养 12 周诱导出与肾病相关的肥胖。喂养 8 周后，给予 100mg RSV/kg 体重/天的口服补充，并继续用高脂肪饮食喂养 4 周。结果表明，RSV 治疗可预防高脂肪饮食引起的肾脏损伤，血清肌酐和尿素氮水平降低，肾小球损伤和肾小管空泡化减轻。此外，RSV 增强了抗氧化酶的活性；改善了与炎症相关的基因表达；并降低了高脂肪饮食小鼠肾脏中的丙二醛、肿瘤坏死因子-α 和白细胞介素-6 浓度。综上所述，RSV 可通过抑制炎症和氧化应激减轻高脂肪饮食诱导的肥胖小鼠的肾脏损伤。
