Ohsawa Masahiro, Maruoka Junya, Inami Chihiro, Iwaki Anna, Murakami Tomoyasu, Ishikura Kei-Ichiro
Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Front Pharmacol. 2018 Nov 30;9:1400. doi: 10.3389/fphar.2018.01400. eCollection 2018.
Ninjin'yoeito (NYT), a traditional Japanese Kampo medicine formula, is used as a remedy for conditions, and physical weakness. Cancer cachexia is seen in advanced cancer patients and is defined by an ongoing loss of skeletal-muscle mass that leads to progressive functional impairment. In the present study, we examined the hypothesis whether NYT improves the functional loss of skeletal muscle cancer cachexia. Male C57/BL 6J mice with B16BF6 melanoma tumor showed decreased expression of myosin heavy chain (MHC) in the gastrocnemius muscle. Moreover, the expression of SOCS3 and phosphorylated STAT3 and AMPK was increased, and the expression of phosphorylated 4E-BP1 was decreased in the gastrocnemius muscle of tumor-bearing mice. These data suggested that amino acid metabolism was altered in tumor-bearing mice, which were normalized by the NYT intervention. The present study showed that NYT might be a novel therapeutic option for the treatment of sarcopenia occurring cancer cachexia.
人参养荣汤（NYT）是一种传统的日本汉方药物配方，用作治疗各种病症和身体虚弱的药物。癌症恶病质在晚期癌症患者中可见，其定义为骨骼肌质量持续丧失，导致进行性功能障碍。在本研究中，我们检验了NYT是否能改善骨骼肌癌症恶病质功能丧失的假设。患有B16BF6黑色素瘤肿瘤的雄性C57/BL 6J小鼠腓肠肌中肌球蛋白重链（MHC）的表达降低。此外，荷瘤小鼠腓肠肌中SOCS3、磷酸化STAT3和AMPK的表达增加，磷酸化4E-BP1的表达降低。这些数据表明荷瘤小鼠的氨基酸代谢发生了改变，而NYT干预使其恢复正常。本研究表明，NYT可能是治疗癌症恶病质相关肌肉减少症的一种新的治疗选择。
