线粒体-细胞骨架相互作用：促进网络功能和重塑的动态关联。
Mitochondrial-cytoskeletal interactions: dynamic associations that facilitate network function and remodeling.
作者信息
Moore Andrew S, Holzbaur Erika L F
机构信息
Department of Physiology, University of Pennsylvania Perelman School of Medicine 638A Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104-6085.
出版信息
Curr Opin Physiol. 2018 Jun;3:94-100. doi: 10.1016/j.cophys.2018.03.003. Epub 2018 Apr 7.
Abstract
Mitochondria are dynamic organelles that can form complex networks in the cell. These networks can be rapidly remodeled in response to environmental changes or to support cellular needs. Mitochondrial dynamics are dependent on interactions with the cellular cytoskeleton - both microtubules and actin filaments. Mitochondrial-cytoskeletal interactions have a well-established role in mitochondrial motility. Recent progress indicates that these interactions also regulate the balance of mitochondrial fission/fusion, as well as mitochondria turnover and mitochondrial inheritance during cell division. We review these advances, and how this work has deepened our understanding of mitochondrial dynamics in the cell.
摘要
线粒体是动态细胞器，可在细胞内形成复杂网络。这些网络能够根据环境变化迅速重塑，或为满足细胞需求提供支持。线粒体动态变化依赖于与细胞骨架（包括微管和肌动蛋白丝）的相互作用。线粒体与细胞骨架的相互作用在调节线粒体运动方面具有既定作用。最近的研究进展表明，这些相互作用还可调控线粒体分裂/融合的平衡，以及细胞分裂过程中的线粒体更新和线粒体遗传。我们将综述这些进展，以及这些研究如何加深了我们对细胞中线粒体动态变化的理解。
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