Unidade de Pesquisa Urogenital, Centro Biomédico, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Departamento de Nutrição Aplicada, Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Int Braz J Urol. 2019 Jan-Feb;45(1):161-168. doi: 10.1590/S1677-5538.IBJU.2018.0547.
High-fat diet-induced obesity is associated with metabolic disorders. The Brazil nut has bioactive substances and has been used to control the damage caused by obesity in several organs. The work intended to show the damage caused by high-fat diet in the bladder wall and if the Brazil nut oil added to the diet could ameliorate or reverse this effect. Sixty-day-old rats were divided into two groups: C (control, n = 30) and HF (high-fat, n = 30) diets. At 90 days, 10 animals of each group were sacrificed. The others were divided into 4 groups: C and HF (animals that maintained their previous diet, n = 10 for each group) and C / Bno and HF / Bno (animals whose control or high-fat diet was supplemented by Brazil nut oil, n = 10 for each group). Sacrifice occurred at 120 days, and the bladders were removed and analyzed. Epithelial height was increased in the HF compared to the C group. In contrast, the C / Bno had a lower epithelial height compared to the others. The percentage of collagen between the detrusor muscle fibers was significantly greater in C / Bno, HF and HF / Bno than in control group. The HF had a larger muscle fiber diameter than the C group, while the C / Bno presented lower values than the HF and HF / Bno groups. HF diets induced bladder wall damage. These changes in the rat's bladder wall were partially reversed by the Bno.
高脂肪饮食诱导的肥胖与代谢紊乱有关。巴西坚果含有生物活性物质，已被用于控制肥胖对几个器官造成的损害。本工作旨在观察高脂肪饮食对膀胱壁的损害，以及巴西坚果油添加到饮食中是否可以改善或逆转这种影响。将 60 日龄大鼠分为两组：C（对照组，n = 30）和 HF（高脂肪组，n = 30）饮食。90 天时，每组处死 10 只动物。其余动物分为 4 组：C 和 HF（继续维持原饮食的动物，每组 n = 10）和 C / Bno 和 HF / Bno（对照组或高脂肪饮食中添加巴西坚果油的动物，每组 n = 10）。120 天时处死动物，取出膀胱并进行分析。HF 组的上皮高度高于 C 组。相比之下，C / Bno 组的上皮高度低于其他组。C / Bno、HF 和 HF / Bno 组膀胱逼尿肌纤维之间的胶原百分比明显高于对照组。HF 组的肌纤维直径大于 C 组，而 C / Bno 组的肌纤维直径低于 HF 和 HF / Bno 组。HF 饮食诱导了膀胱壁损伤。Bno 部分逆转了大鼠膀胱壁的这些变化。
