Medeiros Júnior Jorge Luiz, Oliveira Fabiana Araújo de, Silva Pamella Campos, Furriel Angélica, Sampaio Francisco José Barcellos, Gregório Bianca Martins
State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Acta Cir Bras. 2014;29 Suppl 1:39-44. doi: 10.1590/s0102-86502014001300008.
To investigate the effect of dietary lipid quantity and/or quality on penis morphology in adult rats.
Thirty-eight male Wistar rats were divided into 4 groups: normal lipid diet (NL), high-fat diet rich in saturated fatty acids (HF-S), high-fat diet rich in polyunsaturated fatty acids (HF-P), and high-fat diet rich in saturated and polyunsaturated fatty acids (HF-SP). Blood samples were collected and the penises were removed for histomorphometrical and immunohistochemical analysis.
All high-fat diets promoted an increase in the body mass (p<0.0001). The HF-S and HF-SP groups presented hyperglycemia (p=0.0060), hyperinsulinemia (p=0.0030), and hypercholesterolemia (p=0.0020). Concerning the penis, the high-fat diets led to an increase in the collagen fibers (p<0.0001) and smooth muscle cell density area (p=0.0027), and a decline in the sinusoidal space density area (p<0.0001) and corpus cavernosum cell proliferation (p=0.0003).
Diets rich in saturated and/or polyunsaturated fatty acids promoted overweight and induced penile changes in rodent models, which may lead to the development of erectile dysfunction.
研究饮食中脂质的量和/或质对成年大鼠阴茎形态的影响。
将38只雄性Wistar大鼠分为4组：正常脂质饮食组（NL）、富含饱和脂肪酸的高脂饮食组（HF-S）、富含多不饱和脂肪酸的高脂饮食组（HF-P）以及富含饱和脂肪酸和多不饱和脂肪酸的高脂饮食组（HF-SP）。采集血样并取出阴茎进行组织形态计量学和免疫组织化学分析。
所有高脂饮食均促使体重增加（p<0.0001）。HF-S组和HF-SP组出现高血糖（p=0.0060）、高胰岛素血症（p=0.0030）和高胆固醇血症（p=0.0020）。关于阴茎，高脂饮食导致胶原纤维增加（p<0.0001）和平滑肌细胞密度面积增加（p=0.0027），而窦状隙空间密度面积下降（p<0.0001）以及海绵体细胞增殖减少（p=0.0003）。
富含饱和脂肪酸和/或多不饱和脂肪酸的饮食会导致啮齿动物模型超重并引起阴茎改变，这可能导致勃起功能障碍的发生。
