Laboratório de Cirurgia Experimental, Universidade Estadual do Pará, Belém, PA, Brasil.
Departamento de Pesquisa Cirúrgica e Experimental, Universidade Estadual do Pará, Belém, PA, Brasil.
Int Braz J Urol. 2018 Mar-Apr;44(2):384-389. doi: 10.1590/S1677-5538.IBJU.2017.0143.
The appropriate closure of the urinary bladder is important to many urologic procedures to avoid the formation of fistulas and strictures by excessive fibrosis. This paper presents the alterations in the bladder healing process of rats after the topical use of Copaiba oil (Copaifera reticulata).
Ten male Wistar rats were used and randomly divided into two groups: Control group (CG): injected 1ml/kg of saline solution on the suture line; and Copaiba group (CpG): 0.63ml/kg of copaiba oil applied to the suture line. Euthanasia was performed on the seventh day after surgery. The criteria observed were adherences formation, histopathological modifications and stereology for collagen.
Both groups showed adhesions to the bladder, with no statistically significant difference (p=0.1481). The microscopic evaluation revealed a trend to more severe acute inflammation process on the CpG, but there was statistical difference only in the giant cells reaction (p=0.0472) and vascular proliferation (p=0.0472). The stereology showed no difference.
The copaiba oil modified the healing process, improving the quantity of giant cells and vascular proliferation, but not interfered in the collagen physiology.
在许多泌尿科手术中，适当关闭膀胱对于避免瘘管和狭窄的形成至关重要，这是由过多的纤维化引起的。本文介绍了局部使用库巴油（Copaifera reticulata）后大鼠膀胱愈合过程的变化。
使用 10 只雄性 Wistar 大鼠，并将其随机分为两组：对照组（CG）：在缝线处注射 1ml/kg 的生理盐水；库巴油组（CpG）：在缝线处涂抹 0.63ml/kg 的库巴油。术后第 7 天进行安乐死。观察的标准是粘连形成、组织病理学改变和胶原的体视学。
两组均出现膀胱粘连，但无统计学差异（p=0.1481）。显微镜评估显示 CpG 中急性炎症过程更严重，但巨细胞反应（p=0.0472）和血管增生（p=0.0472）有统计学差异。体视学无差异。
库巴油改变了愈合过程，增加了巨细胞和血管增生的数量，但对胶原生理没有干扰。
