Yonei Yoshikazu, Ichihashi Masamitsu, Takabe Wakako
Nihon Rinsho. 2016 Sep;74(9):1541-1547.
In the anti-aging medicine, we recommend to assess the skin aging by five categories: wrinkle age, spot age, yellow tint age, elasticity age, and moisture age. Photo-aging (oxidative stress) and glycative stress are major causes of age-related deterioration in the skin. Gly- cative stress finally causes skin accumulation of advanced glycation end products(AGEs), inducing yellow tint, and cross linkage between collagen fibers inducing less elastic skin. Oxidative stress causes skin dark spots through the various processes; excess pigment forma- tion and DNA damages. It also causes wrinkle formation associated with matrix metallopro- teinase(MMP) activation and degeneration of collagen and elastin fibers. Study of oxidative and glycative stress may help identify new anti-aging treatments so that we can achieve the skin rejuvenation.
在抗衰老医学中，我们建议从五个方面评估皮肤老化：皱纹年龄、斑点年龄、泛黄年龄、弹性年龄和水分年龄。光老化（氧化应激）和糖基化应激是皮肤与年龄相关的退化的主要原因。糖基化应激最终导致晚期糖基化终产物（AGEs）在皮肤中积累，导致皮肤泛黄，并使胶原蛋白纤维之间发生交联，从而使皮肤弹性降低。氧化应激通过各种过程导致皮肤出现黑斑，如色素过度形成和DNA损伤。它还会导致与基质金属蛋白酶（MMP）激活以及胶原蛋白和弹性纤维变性相关的皱纹形成。对氧化应激和糖基化应激的研究可能有助于确定新的抗衰老治疗方法，从而实现皮肤年轻化。
