School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, 510275, PR China; Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, PR China.
Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China; Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, PR China.
Environ Pollut. 2019 Mar;246:257-263. doi: 10.1016/j.envpol.2018.12.002. Epub 2018 Dec 7.
This work aimed to determine the concentrations of parabens and triclosan (TCS) in shellfish from coastal waters of Shenzhen, South China. A method of isotope dilution with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used to determine TCS and five paraben analogues, including methyl paraben (MeP), ethyl paraben (EtP), propyl paraben (PrP), butyl paraben (BuP), and benzyl paraben (BeP), in 186 shellfish samples covering eight species. Concentrations of parabens and TCS were 0.13-25.5 ng/g wet weight (ww) and <LOQ-6.51 ng/g ww, respectively, indicating their ubiquitous contamination in Shenzhen coastal waters. MeP was the most predominant paraben, followed by EtP and PrP. These three analogues accounted for more than 95% of the total concentrations of parabens. The "high" estimated daily intakes of parabens and TCS with the 95th percentage concentrations were estimated to be 2.15-26.1 and 0.41-10.3 ng/kg bw/day, respectively, much lower than the acceptable dietary intakes of parabens (1 × 10 ng/kg bw/day) and TCS (200 ng/kg bw/day), indicating no significant human health risks from shellfish consumption in the studied region. To our knowledge, this is the first report on the occurrences of parabens and TCS in shellfish products from Shenzhen coastal waters.
本研究旨在测定中国南方深圳沿海贝类中防腐剂（对羟基苯甲酸酯）和三氯生（TCS）的浓度。采用同位素稀释高效液相色谱-串联质谱法（HPLC-MS/MS），对 186 个贝类样本（涵盖 8 个种类）中的 TCS 和 5 种对羟基苯甲酸酯（包括甲基对羟基苯甲酸酯（MeP）、乙基对羟基苯甲酸酯（EtP）、丙基对羟基苯甲酸酯（PrP）、丁基对羟基苯甲酸酯（BuP）和苄基对羟基苯甲酸酯（BeP））进行了检测。研究结果表明，贝类中对羟基苯甲酸酯和 TCS 的浓度分别为 0.13-25.5 ng/g 湿重（ww）和 <LOQ-6.51 ng/g ww，表明深圳沿海水域普遍存在这两种污染物的污染情况。MeP 是最主要的对羟基苯甲酸酯，其次是 EtP 和 PrP。这三种类似物占对羟基苯甲酸酯总量的 95%以上。通过 95%百分位浓度估计，对羟基苯甲酸酯和 TCS 的“高”日估计摄入量分别为 2.15-26.1 和 0.41-10.3 ng/kg bw/day，远低于对羟基苯甲酸酯（1×10 ng/kg bw/day）和 TCS（200 ng/kg bw/day）的可接受膳食摄入量，表明在所研究地区，贝类消费不会对人体健康造成显著风险。据我们所知，这是首次报道深圳沿海贝类产品中存在对羟基苯甲酸酯和 TCS。
