Chen Xueyan, Zhong Shihua, Zhang Miao, Zhong Weichuan, Bai Shi, Zhao Yang, Li Chun, Lu Shaoyou, Li Wenbo
Department of Clinical Laboratory, The People's Hospital of Longhua, Shenzhen, 518109 China.
Agricultural Product Quality Safety Inspection and Testing Center of Shenzhen, 518055 Shenzhen, China.
J Environ Health Sci Eng. 2021 Jan 12;19(1):251-259. doi: 10.1007/s40201-020-00599-1. eCollection 2021 Jun.
The usage of parabens, bisphenol A and triclosan in diverse consumer products is in widespread. Nevertheless, there are limited data concerning exposure to these chemicals in human being, especially in primiparas. Biomonitoring of chemicals in primiparas is useful for the estimation of chemical exposure risks for both primiparas and their offspring. This study aims to investigate urinary levels of parabens, bisphenol A and triclosan of 84 primiparas from Shenzhen, China and to evaluate their potential health risks. Methyl, ethyl, and n-propyl parabens bisphenol A and triclosan exhibited high detection rates (DRs) (> 97%) in urine samples, suggesting that primiparas are exposed to them widely. The median concentrations of methyl, ethyl, and n-propyl parabens, bispenol A and triclosan in urine were 2.14, 4.10, 0.46, 1.30 and 3.00 µg/L, respectively. Ethyl paraben was the predominant paraben accounting for nearly half of Σparabens (The sum concentrations of methyl, ethyl, n-propyl parabens). Positive associations with significance ( < 0.05) were found between the usage of plastic containers and urinary concentrations of ethyl paraben or BPA, indicating plastic containers might be an important factor influencing primipara exposure to these two chemicals. Urinary concentrations of methyl paraben were positively associated ( < 0.05) with the time of computer use by participant, suggesting that indoor dust might constitute an important source of parabens. The estimated daily intakes of parabens, bisphenol A and triclosan contrasted with the acceptable daily intakes in a comparatively low level. The hazard quotients (HQs) of these chemicals were all less than 1, suggesting no health risks for primiparas from South China.
The online version contains supplementary material available at 10.1007/s40201-020-00599-1.
对羟基苯甲酸酯、双酚A和三氯生在各种消费品中的使用十分广泛。然而，关于人类，尤其是初产妇接触这些化学物质的数据有限。对初产妇进行化学物质生物监测有助于评估初产妇及其后代的化学物质暴露风险。本研究旨在调查来自中国深圳的84名初产妇尿液中对羟基苯甲酸酯、双酚A和三氯生的水平，并评估其潜在健康风险。对羟基苯甲酸甲酯、乙酯、正丙酯、双酚A和三氯生在尿液样本中的检出率很高（>97%），表明初产妇广泛接触这些物质。尿液中对羟基苯甲酸甲酯、乙酯、正丙酯、双酚A和三氯生的中位数浓度分别为2.14、4.10、0.46、1.30和3.00μg/L。对羟基苯甲酸乙酯是主要的对羟基苯甲酸酯，占总对羟基苯甲酸酯（对羟基苯甲酸甲酯、乙酯、正丙酯的总浓度）的近一半。在塑料容器的使用与尿液中对羟基苯甲酸乙酯或双酚A的浓度之间发现了具有显著意义（<0.05）的正相关，表明塑料容器可能是影响初产妇接触这两种化学物质的一个重要因素。尿液中对羟基苯甲酸甲酯的浓度与参与者使用电脑的时间呈正相关（<0.05），表明室内灰尘可能是对羟基苯甲酸酯的一个重要来源。对羟基苯甲酸酯、双酚A和三氯生的估计每日摄入量与可接受的每日摄入量相比处于相对较低水平。这些化学物质的危害商数（HQs）均小于1，表明华南地区的初产妇没有健康风险。
在线版本包含可在10.1007/s40201-020-00599-1获取的补充材料。
