NS5 抑制 I 型干扰素信号通路。
Suppression of Type I Interferon Signaling by NS5.
机构信息
Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA.
Graduate Program in Cell, Molecular and Developmental Biology, University of California, Riverside, Riverside, CA 92521, USA.
出版信息
Viruses. 2018 Dec 14;10(12):712. doi: 10.3390/v10120712.
Abstract
Type I interferon (IFN-I) is the first line of mammalian host defense against viral infection. To counteract this, the flaviviruses, like other viruses, have encoded a variety of antagonists, and use a multi-layered molecular defense strategy to establish their infections. Among the most potent antagonists is non-structural protein 5 (NS5), which has been shown for all disease-causing flaviviruses to target different steps and players of the type I IFN signaling pathway. Here, we summarize the type I IFN antagonist mechanisms used by flaviviruses with a focus on the role of NS5 in regulating one key regulator of type I IFN, signal transducer and activator of transcription 2 (STAT2).
摘要
I 型干扰素（IFN-I）是哺乳动物宿主防御病毒感染的第一道防线。为了对抗这一点，黄病毒与其他病毒一样，编码了多种拮抗剂，并利用多层次的分子防御策略来建立感染。其中最有效的拮抗剂是非结构蛋白 5（NS5），所有致病黄病毒都已证明靶向 I 型 IFN 信号通路的不同步骤和参与者。在这里，我们总结了黄病毒使用的 I 型 IFN 拮抗剂机制，重点介绍 NS5 在调节 I 型 IFN 的一个关键调节剂信号转导和转录激活因子 2（STAT2）中的作用。
相似文献
1
Suppression of Type I Interferon Signaling by NS5.
Viruses. 2018 Dec 14;10(12):712. doi: 10.3390/v10120712.
2
Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism.
J Virol. 2019 Jun 28;93(14). doi: 10.1128/JVI.00151-19. Print 2019 Jul 15.
3
Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling.
Cell Host Microbe. 2016 Jun 8;19(6):882-90. doi: 10.1016/j.chom.2016.05.009. Epub 2016 May 19.
4
Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist.
J Virol. 2005 Oct;79(20):12828-39. doi: 10.1128/JVI.79.20.12828-12839.2005.
5
NS5-independent Ablation of STAT2 by Zika virus to antagonize interferon signalling.
Emerg Microbes Infect. 2021 Dec;10(1):1609-1625. doi: 10.1080/22221751.2021.1964384.
6
The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon Signaling.
J Virol. 2017 Jan 18;91(3). doi: 10.1128/JVI.01970-16. Print 2017 Feb 1.
7
The NS5 protein of the virulent West Nile virus NY99 strain is a potent antagonist of type I interferon-mediated JAK-STAT signaling.
J Virol. 2010 Apr;84(7):3503-15. doi: 10.1128/JVI.01161-09. Epub 2010 Jan 27.
8
Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein.
J Virol. 2017 Jun 26;91(14). doi: 10.1128/JVI.00163-17. Print 2017 Jul 15.
9
The Role of NS5 Protein in Determination of Host Cell Range for Yellow Fever Virus.
DNA Cell Biol. 2019 Dec;38(12):1414-1417. doi: 10.1089/dna.2019.5115. Epub 2019 Oct 18.
10
Mechanisms of evasion of the type I interferon antiviral response by flaviviruses.
J Interferon Cytokine Res. 2009 Sep;29(9):521-30. doi: 10.1089/jir.2009.0069.
引用本文的文献
1
Dengue Virus Infection: Immune Response and Therapeutic Targets.
Am J Trop Med Hyg. 2024 Nov 12;112(1):37-44. doi: 10.4269/ajtmh.23-0545. Print 2025 Jan 8.
2
Etravirine Prevents West Nile Virus and Chikungunya Virus Infection Both In Vitro and In Vivo by Inhibiting Viral Replication.
Pharmaceutics. 2024 Aug 23;16(9):1111. doi: 10.3390/pharmaceutics16091111.
3
Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2.
Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2403235121. doi: 10.1073/pnas.2403235121. Epub 2024 Aug 15.
4
Integrated control strategies for dengue, Zika, and Chikungunya virus infections.
Front Immunol. 2023 Dec 18;14:1281667. doi: 10.3389/fimmu.2023.1281667. eCollection 2023.
5
Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.
EMBO Rep. 2023 Dec 6;24(12):e57424. doi: 10.15252/embr.202357424. Epub 2023 Oct 20.
6
Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation.
Proc Natl Acad Sci U S A. 2023 Jun 6;120(23):e2220005120. doi: 10.1073/pnas.2220005120. Epub 2023 May 30.
7
Evaluation of NS4A, NS4B, NS5 and 3'UTR Genetic Determinants of WNV Lineage 1 Virulence in Birds and Mammals.
Viruses. 2023 Apr 29;15(5):1094. doi: 10.3390/v15051094.
8
Flavivirus prM interacts with MDA5 and MAVS to inhibit RLR antiviral signaling.
Cell Biosci. 2023 Jan 13;13(1):9. doi: 10.1186/s13578-023-00957-0.
9
Splicing factor SF3B3, a NS5-binding protein, restricts ZIKV infection by targeting GCH1.
Virol Sin. 2023 Apr;38(2):222-232. doi: 10.1016/j.virs.2022.12.005. Epub 2022 Dec 23.
10
Immune signature atlas of vaccines: learning from the good responders.
Nat Immunol. 2022 Dec;23(12):1654-1656. doi: 10.1038/s41590-022-01361-5.
本文引用的文献
1
Pervasive tertiary structure in the dengue virus RNA genome.
Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11513-11518. doi: 10.1073/pnas.1716689115. Epub 2018 Oct 19.
2
Subgenomic flaviviral RNAs: What do we know after the first decade of research.
Antiviral Res. 2018 Nov;159:13-25. doi: 10.1016/j.antiviral.2018.09.006. Epub 2018 Sep 11.
3
COMRADES determines in vivo RNA structures and interactions.
Nat Methods. 2018 Oct;15(10):785-788. doi: 10.1038/s41592-018-0121-0. Epub 2018 Sep 10.
4
Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection.
Cell Microbiol. 2018 Aug;20(8):e12848. doi: 10.1111/cmi.12848. Epub 2018 Apr 24.
5
Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir.
Elife. 2018 Mar 20;7:e31919. doi: 10.7554/eLife.31919.
6
Glutathionylation of dengue and Zika NS5 proteins affects guanylyltransferase and RNA dependent RNA polymerase activities.
PLoS One. 2018 Feb 22;13(2):e0193133. doi: 10.1371/journal.pone.0193133. eCollection 2018.
7
Causes and Consequences of Flavivirus RNA Methylation.
Front Microbiol. 2017 Dec 5;8:2374. doi: 10.3389/fmicb.2017.02374. eCollection 2017.
8
Dengue virus activates cGAS through the release of mitochondrial DNA.
Sci Rep. 2017 Jun 15;7(1):3594. doi: 10.1038/s41598-017-03932-1.
9
Antagonism of type I interferon by flaviviruses.
Biochem Biophys Res Commun. 2017 Oct 28;492(4):587-596. doi: 10.1016/j.bbrc.2017.05.146. Epub 2017 May 31.
10
Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein.
J Virol. 2017 Jun 26;91(14). doi: 10.1128/JVI.00163-17. Print 2017 Jul 15.
Zotero 插件