Viseu Teresa, Lopes Carla M, Fernandes Eduarda, Oliveira Maria Elisabete C D Real, Lúcio Marlene
CF-UM-UP-Centre of Physics of Universities of Minho and Porto, Departament of Physics of University of Minho, Escola de Ciências, Campus de Gualtar, 4710-057 Braga, Portugal.
FP-ENAS/CEBIMED-Fernando Pessoa Energy, Environment and Health Research Unit/Biomedical Research Centre, Faculty of Health Sciences, Fernando Pessoa University, 4249-004 Porto, Portugal.
Pharmaceutics. 2018 Dec 16;10(4):282. doi: 10.3390/pharmaceutics10040282.
Many graphene-based materials (GBNs) applied to therapy and diagnostics (theranostics) in cancer have been developed. Most of them are hybrid combinations of graphene with other components (e.g, drugs or other bioactives, polymers, and nanoparticles) aiming toward a synergic theranostic effect. However, the role of graphene in each of these hybrids is sometimes not clear enough and the synergic graphene effect is not proven. The objective of this review is to elaborate on the role of GBNs in the studies evaluated and to compare the nanoformulations in terms of some of their characteristics, such as therapeutic outcomes and toxicity, which are essential features for their potential use as bionanosystems. A systematic review was carried out using the following databases: PubMed, Scopus, and ISI Web of Science (2013⁻2018). Additional studies were identified manually by consulting the references list of relevant reviews. Only English papers presenting at least one strategy for cancer therapy and one strategy for cancer diagnostics, and that clearly show the role of graphene in theranostics, were included. Data extraction and quality assessment was made by reviewer pairings. Fifty-five studies met the inclusion criteria, but they were too heterogeneous to combine in statistical meta-analysis. Critical analysis and discussion of the selected papers are presented.
许多应用于癌症治疗与诊断（治疗诊断学）的基于石墨烯的材料（GBN）已被开发出来。其中大多数是石墨烯与其他成分（如药物或其他生物活性物质、聚合物和纳米颗粒）的混合组合，旨在实现协同治疗诊断效果。然而，石墨烯在这些混合物中的作用有时还不够明确，且协同石墨烯效应也未得到证实。本综述的目的是阐述GBN在已评估研究中的作用，并根据其一些特性（如治疗效果和毒性）对纳米制剂进行比较，这些特性是其作为生物纳米系统潜在用途的基本特征。使用以下数据库进行了系统综述：PubMed、Scopus和ISI科学网（2013 - 2018年）。通过查阅相关综述的参考文献列表手动识别了其他研究。仅纳入了至少呈现一种癌症治疗策略和一种癌症诊断策略，且清楚显示石墨烯在治疗诊断学中作用的英文论文。数据提取和质量评估由评审员配对完成。55项研究符合纳入标准，但它们过于异质，无法合并进行统计荟萃分析。对所选论文进行了批判性分析和讨论。
