Kabadayi Sahin Esra, Caykoylu Ali, Senat Almila, Erel Ozcan
Department of Psychiatry, Abant Izzet Baysal University, Izzet Baysal Mental Health Research and Training Hospital, Bolu, Turkey.
Department of Psychiatry, Ankara Yildirim Beyazit University Medical School, Ankara, Turkey.
Acta Neuropsychiatr. 2019 Apr;31(2):100-105. doi: 10.1017/neu.2018.33. Epub 2018 Dec 18.
To investigate oxidative stress parameters [total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase (PON), arylesterase (ARE) and thiol-disulphide homeostasis] in patients who were diagnosed as having somatic symptom disorder in accordance with Diagnostic and Statistical Manual of Mental Disorders-5.
The study included 41 medication-free patients with somatic symptom disorder and 47 age, sex, and sociodemographic-matched healthy individuals. The patients were administered the Patient Health Questionnaire-15, Somatic Symptom Amplification Scale, Beck Depression Inventory, and Beck Anxiety Inventory. TOS, TAS, OSI, PON, ARE thiol, disulphide levels, and routine biochemical parameters were compared between the two groups.
TOS, OSI, disulphide levels, disulphide/native thiol, and disulphide/total thiol ratios were found significantly higher in the patient group compared with the control group (p < 0.001). There was no significant difference in PON, ARE, and TAS parameters between the two groups (p > 0.05).
This study showed that the level of oxidants increased and oxidative balance was impaired in somatic symptom disorder. Oxidative stress may play a role in the aetiopathogenesis of this disorder. This is the first study to report an association between oxidative stress and somatic symptom disorder.
根据《精神疾病诊断与统计手册》第5版，调查被诊断为躯体症状障碍患者的氧化应激参数[总氧化剂状态（TOS）、总抗氧化剂状态（TAS）、氧化应激指数（OSI）、对氧磷酶（PON）、芳基酯酶（ARE）和硫醇-二硫键稳态]。
该研究纳入了41例未服用药物的躯体症状障碍患者以及47例年龄、性别和社会人口统计学匹配的健康个体。对患者进行了患者健康问卷-15、躯体症状放大量表、贝克抑郁量表和贝克焦虑量表评估。比较了两组之间的TOS、TAS、OSI、PON、ARE硫醇、二硫键水平以及常规生化参数。
与对照组相比，患者组的TOS、OSI、二硫键水平、二硫键/天然硫醇以及二硫键/总硫醇比值显著更高（p < 0.001）。两组之间的PON、ARE和TAS参数无显著差异（p > 0.05）。
本研究表明，躯体症状障碍患者的氧化剂水平升高，氧化平衡受损。氧化应激可能在该疾病的病因发病机制中起作用。这是第一项报道氧化应激与躯体症状障碍之间关联的研究。
